Ashwagandha and valerian root are popular herbs that can function as natural sleep aids. But they take completely different routes to get you to sleep. Here's how their effects on cortisol, GABA, and sleep quality stack up — and which one matches your nighttime struggles.

Overview

  • Ashwagandha vs. valerian root comes down to what’s keeping you up: one herb may help with stress-driven sleeplessness, the other with falling asleep faster.
  • Ashwagandha is an adaptogen that research suggests may help lower cortisol and support long-term stress resilience.
  • Valerian root interacts with your brain’s GABA system, which may help quiet the nervous system for a more sedative effect.
  • Both herbs vary widely in potency, so standardized extracts (like Shoden® for ashwagandha) can help ensure consistent quality.
  • Because they work on different pathways, ashwagandha and valerian root may complement each other or be replaced by formulations targeting both systems.

Your body has more than one way to keep you awake. Stress hormones can do it. An overactive nervous system can do it. Sometimes both at once. They’re separate systems — cortisol regulating your stress response, GABA regulating how easily your brain quiets down — and calming one doesn’t automatically calm the other.

So when you’re deciding between ashwagandha and valerian root, the real question is: which system needs the help? Is it your cortisol keeping you wired, or your nervous system that won’t quiet down? 🤔

Both are natural herbs used to support sleep, but they work differently, and that matters when you’re deciding which one to try.

Ashwagandha vs. Valerian Root: How They Work

To understand which herb fits your situation, it helps to understand how they interact with your body. They might both lead to sleep, but they take different roads to get there. 

💤 Learn More → The Best Supplements for Sleep

Ashwagandha: An Adaptogen for Stress and Sleep

Ashwagandha (Withania somnifera) is an adaptogen, meaning it may help your body handle stress more effectively. Research suggests it can support a more balanced stress response, in part by influencing cortisol, your body’s primary stress hormone.1,2 

It’s less about knocking you out and more about calming the internal noise that keeps your mind and body from settling into sleep.

Valerian Root: A Natural GABA-Boosting Sedative

Valerian root (Valeriana officinalis) functions more like a traditional sedative. It interacts with your brain’s GABA receptors — the same pathway targeted by many prescription sleep aids — which may help quiet the nervous system and bring on that drowsy feeling.3

There’s an important distinction between these two approaches: sedation and restoration aren’t the same thing. Sedation quiets the nervous system in the moment, while restoration means working with your body’s own sleep rhythms so you wake up genuinely recharged. The most effective sleep support often addresses both sides of that equation.

Ashwagandha for Sleep: Cortisol, Stress, and Sleep Quality

How Ashwagandha May Lower Cortisol

Ashwagandha is an evergreen shrub used in Ayurvedic medicine for thousands of years. Its benefits come largely from compounds called withanolides.

When you’re stressed, your cortisol levels spike. In the short term, that’s actually helpful from a survival perspective. We need cortisol. 

But when cortisol stays elevated, it signals “danger” to your brain for longer periods of time, which is the opposite of what you need for deep, restorative sleep.

Research shows that high-concentration ashwagandha extracts may help bring cortisol levels down. In one study, participants taking a concentrated root extract experienced about a 28% reduction in cortisol over 60 days, compared to roughly 8% in the placebo group.2 A later study also found reductions in morning cortisol levels among adults taking ashwagandha.1

By helping regulate cortisol when it’s elevated, ashwagandha may support a shift away from constant “fight or flight” and toward a calmer state that’s more compatible with good sleep.

Ashwagandha and Sleep Quality Research

While it’s known for stress management, ashwagandha may also be a strong sleep ally. Clinical studies using specific extracts have shown its ability to improve overall sleep quality.

One study found that participants taking ashwagandha, including those with insomnia, saw improvements in time to fall asleep compared to the placebo group.4

But if you’ve ever slept through the night and still woken up feeling exhausted, you know that falling asleep isn’t the whole story. Quality matters.

In another study of adults who regularly felt unrested after sleep, 72% of those taking ashwagandha reported an improvement in sleep quality, compared to 29% in the placebo group.5 While these were self-reported outcomes, the results suggest ashwagandha may support not just falling asleep, but waking up feeling more rested.

Who Should Consider Ashwagandha for Sleep

Not every sleep problem has the same root cause (pun intended). 

Ashwagandha is likely your best fit if:

  • You’re tired but wired. You’re exhausted, but your mind won’t stop racing.
  • A full night of sleep isn’t restful. You can sleep for hours but wake up feeling like you barely closed your eyes.
  • Stress lives in your head rent-free. You want support that helps recalibrate your stress response over time, not just a sedative nudge.

👉 TL;DR: Ashwagandha doesn’t work like a sleeping pill. It may help by dialing down the cortisol and stress keeping your brain on high alert. It supports more restorative sleep over time.

Valerian Root for Sleep: GABA, Relaxation, and Falling Asleep Faster

How Valerian Root Supports GABA and Relaxation

Valerian root has been used for centuries. Its use dates back to ancient Greece and Rome, where it was associated with sleep support and calming the nerves. Its activity comes from the root itself, which contains valerenic acid — the compound behind its distinctively earthy, strong aroma. (That unmistakable smell when you open a bottle of valerian capsules? 🫢 That’s valerenic acid.)

Scientists have hypothesized that valerian’s active compounds may support relaxation in part by influencing GABA, one of the brain’s main inhibitory neurotransmitters. GABA is naturally produced by the brain, and it helps quiet nerve cell activity.6 You can think of it as a volume knob for your nervous system, helping turn down some of that internal chatter. Research suggests valerian may help enhance that signaling, which could extend the sense of calm.3

Valerian Root and Sleep Research

Valerian is most studied for its potential to help people fall asleep faster — in other words, to reduce what’s known as “sleep latency.”

Some research suggests valerian may reduce the time it takes to fall asleep and improve how people rate their own sleep quality, though the effects are generally modest and not consistent across every study.3

A 2023 study using a standardized extract of valerian root found improvements in how quickly adults with mild sleep complaints fell asleep and how long they stayed asleep, measured through wrist-worn activity trackers.7

The mixed results across studies are likely due to differences in how they were designed and which extracts were used — one reason why finding a quality, standardized source of the ingredient matters.

Who Should Consider Valerian Root

The way valerian root supports GABA makes it the more targeted option for falling asleep faster. 

Consider it if:

  • Falling asleep is the hard part. Your main struggle is the gap between getting into bed and actually drifting off.
  • You don’t feel tired when you should be. You want something that helps your body feel ready for sleep in the moment.
  • Chronic stress? Don’t know her. Ongoing stress or racing thoughts aren’t the primary thing keeping you up at night.

Ashwagandha vs. Valerian Root: A Side-by-Side Comparison

Here’s a snapshot of how these two herbs stack up as sleep supplements across key categories.

💡 Pro Tip: If you’re choosing between these two, consider your primary symptom. Trouble winding down at night? Valerian root may help. Feeling overwhelmed by long-term stress that bleeds into your sleep? Ashwagandha might be worth exploring.

Sleep Quality vs. Sleep Onset

If you stare at the clock for an hour before falling asleep, valerian’s GABA support may help quiet your nervous system enough to drift off sooner.

Ashwagandha may be a better option if you’re looking for broader sleep support, especially when stress is part of the picture. It appears to support a healthier stress response, which may help with staying asleep and improving overall sleep quality. Recent meta-analyses suggest modest benefits for sleep in adults, though research is still evolving.8

Stress and Relaxation Support

Ashwagandha stands out here. As an adaptogen, it’s thought to support the body’s physiological stress response rather than simply masking symptoms. Studies have shown meaningful reductions in perceived stress among participants using ashwagandha compared to placebo.1,2

Valerian works differently. It’s generally considered more sedating and may help calm the nervous system in the short term. (Ashwagandha doesn’t really make you sleepy, per se.) However, research hasn’t found enough high-quality evidence supporting its use specifically for anxiety.9 If you want to build resilience to stress over time, ashwagandha is the stronger choice.

Safety and Side Effects of Ashwagandha and Valerian Root

Both herbs are generally considered safe for short-term use, but quality matters.

  • Ashwagandha: Generally well-tolerated. However, there are some reported drug and medical interactions and rare reports of adverse reactions with certain ashwagandha products. Always talk with a healthcare provider before taking.10
  • Valerian Root: Can cause vivid dreams, upset stomach, or morning grogginess in some people. It’s often advised to avoid driving or operating machinery after taking it, which makes sense given its sedative nature.

How Your Gut Microbiome Connects to Sleep

The path to better sleep may run through your gut. Your gut microbiome helps produce and metabolize neurotransmitters like GABA, and it communicates with your brain through the gut-brain axis, a bidirectional signaling network involved in regulating stress and sleep-wake cycles.

Dirk Gevers, Ph.D., Seed’s Chief Scientific Officer, explains why targeting symptoms in isolation misses the point. “Stress, sleep, and gut health are deeply interconnected. Supporting the gut microbiome, a key foundation of the gut-brain axis, helps the body reestablish the conditions needed for rest and recovery.”

That’s one reason formulations designed to support both sleep pathways and the gut microbiome may offer a more complete approach than single-ingredient herbs alone.

Targeting Multiple Sleep Pathways with PM-02™

The typical melatonin supplement contains 5-10 mg of melatonin, which is a lot more than your brain naturally produces. Over time, this can disrupt your body’s own melatonin production.

PM-02™ Sleep + Restore takes a different approach, targeting the same pathways as ashwagandha and valerian root with a focus on precision:

  • For the Stress Pathway: PM-02™ uses Shoden® ashwagandha, a clinically studied, high-potency extract shown to support restorative sleep and help balance cortisol levels.5
  • For the GABA Pathway: Instead of relying on herbal extracts to indirectly influence GABA, PM-02™ delivers a fermented form that mimics what your body already produces — direct support for relaxation, more consistent results.
  • For the Melatonin Pathway: A bioidentical dose with dual-phase release helps you fall asleep and stay asleep over 7 hours — without the grogginess of mega-dose melatonin.

Seed’s sleep support formula is delivered using ViaCap®, Seed’s proprietary capsule-in-capsule technology, ensuring targeted delivery to both your body and your microbiome.

The Key Insight

Your sleep system runs like an orchestra. Cortisol sets the tempo, GABA manages the volume, and melatonin cues the final movement. When any section falls out of sync, the whole performance suffers.

That’s what makes the ashwagandha vs. valerian root question so personal. Ashwagandha works on the conductor (your stress response) while valerian nudges the strings section toward quiet. Neither is universally “better,” because the answer depends on which part of your sleep system needs the most support.

The most restorative sleep may come from addressing both: calming the mind’s stress signals and easing the nervous system into rest, all while honoring your body’s natural rhythms rather than overriding them.

🌱 The deepest rest isn’t forced. It’s cultivated, one pathway at a time.

Frequently Asked Questions (FAQs)

What’s Better for Sleep: Valerian Root or Ashwagandha?

It depends on what’s keeping you awake. Valerian is primarily studied for its sedative effects and may help some people fall asleep faster, especially with occasional sleeplessness.3 Ashwagandha is more often researched for stress support, and if your sleep struggles seem linked to ongoing stress, it may help support a healthier stress response and improve overall sleep quality over time.1,2 

Neither is a guaranteed fix, but the right choice often comes down to whether your main challenge is falling asleep or managing the racing thoughts that keep you awake.

Can You Take Ashwagandha and Valerian Root Together?

Yes, most people can. Because they work through different mechanisms — ashwagandha on the endocrine system (hormones and cortisol) and valerian on the central nervous system (GABA and other neurotransmitters) — they can be complementary.1,2,3 

That said, combining supplements isn’t always better, and dosing matters. Rather than mixing products on your own, many people prefer formulas that are intentionally designed and dosed to target stress and sleep pathways more precisely. Always check with a healthcare professional, especially if you’re taking other medications.

What Is the Downside of Valerian Root?

Morning grogginess. The most common downside is a “hangover” effect similar to some over-the-counter sleep aids. 

Some people also report vivid or disturbing dreams and mild digestive upset. Because valerian acts similarly to a sedative, it should not be taken with alcohol or other sedating medications.

What Is the Strongest Herb for Calming Stress?

Ashwagandha is one of the most-studied herbal adaptogens for calming stress and supporting a busy mind.1,2 Kava is another herb often cited for its calming effects, though it carries safety concerns.11,12 For racing thoughts before bed, the combination of an adaptogen like ashwagandha (for stress) and GABA-supporting ingredients (for nervous system calm) is often the most effective approach.

Citations

  1. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine (Baltimore). 2019;98(37):e17186.
  2. Chandrasekhar K, Kapoor J, Anishetty S. Indian J Psychol Med. 2012;34(3):255.
  3. Shinjyo N, Waddell G, Green J. J Evid Based Integr Med. 2020;25(25).
  4. Langade D, Thakare V, Kanchi S, Kelgane S. J Ethnopharmacol. 2021;264:113276.
  5. Deshpande A, Irani N, Balkrishnan R, Benny IR. Sleep Med. 2020;72:28-36.
  6. Chen R. StatPearls. 2023.
  7. Shekhar H. Adv Ther. 2023.
  8. Cheah KL, Norhayati MN, Yaacob LH, Rahman RA. PLoS One. 2021;16(9):e0257843.
  9. Miyasaka LS, Atallah AN, Soares BG. Cochrane Database Syst Rev. 2006;(4).
  10. Björnsson HK, Björnsson ES, Avula B, et al. Liver Int. 2020;40(4):825-29.
  11. Thompson R, Ruch W, Hasenöhrl RU. Hum Psychopharmacol. 2004;19(4):243-50.
  12. Teschke R, Sarris J, Lebot V. Phytomedicine. 2011;18(2-3):96-103.

Sydni Rubio

Written By

Sydni Rubio

Sydni is a science writer with a background in biology and chemistry. As a Master's student, she taught bacteriology labs and conducted research for her thesis, which focused on the microbiology and genetics of symbiotic amoebae and bacteria. Her passion for translating complex scientific concepts into clear, engaging content later led to her role as Editor-in-Chief for a mental health blog. Outside of writing, she loves to learn about new things with her curious son.