Reference

PM-02™ Sleep + Restore

PM-02™ Sleep + Restore
Overview
Formulation
Directions for Use
Key Ingredients
Ingredient-Specific Benefit Studies
Testing
Interactions
Reference Library — PM-02™
Overview
Formulation
Directions for Use
Key Ingredients
Ingredient-Specific Benefit Studies
Testing
Interactions

PM-02™ Sleep + Restore works with your body to help you fall asleep faster and rest more deeply, with bioidentical melatonin and clinically studied ashwagandha. Powered by Seed’s ViaCap® delivery system, PM-02™ works in collaboration with the body and microbiome to support sleep and stress signaling—without dependency or next-day haze.*

Gut-Sleep Connection

Emerging science reveals that the gut microbiome is inextricably linked to sleep—helping to calibrate circadian rhythms and support the production of key compounds and neurotransmitters associated with sleep, such as melatonin and GABA. Together, this gut-brain communication plays a vital role in how deeply you rest and how clearly you wake.

Formulation

Japanese wasabi (Wasabia japonica) extract (root) [2% isothiocyanates]

Japanese pagoda tree (Sophora japonica) extract (flower) [95% quercetin]

GABA [Gamma-aminobutyric acid] (Lactobacillus brevis-derived postbiotic)

Shoden® Ashwagandha (Withania somnifera) extract (root and leaf) [35% withanolide glycosides]

Coenzyme PQQ [Pyrolloquinoline quinone] disodium salt

Melatonin (rapid release)

MicroActive® Melatonin (7-hour sustained release)

Thiamine [Vitamin B1] (as thiamine hydrochloride)

Riboflavin [Vitamin B2] (as free riboflavin)

Niacin [Vitamin B3] (as nicotinic acid)

Directions for Use

Take 1 capsule, nightly, 30-60 minutes before bedtime.

Do not operate heavy machinery or drive when taking melatonin.

PM-02™ is designed for nightly use, unlike many traditional sleep aids. Its adaptogenic ingredients are selected for their ability to build in your system and deliver benefits that increase with regular use.*

Key Ingredients

Melatonin is a hormone your body naturally produces to regulate sleep—but factors like screen exposure, jet lag, shift work, and aging can reduce your body’s production, making it harder to fall and stay asleep. Most melatonin supplements help increase sleep onset, but wear off quickly—often within 4 hours. Our formula includes a gentle, non-habit-forming 500mcg dose, split between fast-acting melatonin, which helps you fall asleep, and MicroActive® Melatonin, which helps you stay asleep.*

MicroActive® melatonin uses an extended-release delivery system that gradually releases over 7 hours, helping support a full, uninterrupted night of rest. Unlike high-dose melatonin supplements that can cause spikes, crashes, and morning grogginess, this low, steady dose mirrors your body’s natural melatonin cycle to help you fall and stay asleep.

Shoden® is a low-dose, highly potent and bioavailable form of ashwagandha that offers benefits for stress and sleep support—without requiring a large dose. As an adaptogen, ashwagandha helps the body better adapt to stress by regulating cortisol and balancing the nervous system.

Shoden® has also been shown to influence GABA responses preclinically, which may have a calming effect and support deeper sleep.


Its antioxidant and inflammatory-balancing properties help protect the body from cellular damage, and it has been shown to boost brain-supporting factors like BDNF, which is associated with memory and learning.*

This complex, formulated with pterostilbene and spermidine, promotes mitochondrial renewal, protects against oxidative stress, and supports overall energy metabolism—key processes that lay the groundwork for restful, restorative sleep and healthy aging.*



Pterostilbene and spermidine have been shown to improve mitochondrial function and regulation in vitro. Pterostilbene has also been shown to positively influence the gut microbiome and help regulate sleep-related pathways in a preclinical study related to jet lag and circadian disruption.1

1Y.-C. Koh, P.-S. Lee, Y.-L. Kuo, K. Nagabhushanam, C.-T. Ho, M.-H. Pan, Dietary Pterostilbene and Resveratrol Modulate the Gut Microbiota Influenced by Circadian Rhythm Dysregulation. Mol. Nutr. Food Res. 2021, 65, 2100434

Ingredient-Specific Benefit Studies

BenefitStudies
Non-Habit Forming (Bioidentical Dose of Melatonin)Zhdanova et al. Sleep. 1996
Zhdanova et al. J Clin Endocrinol Metab. 2001†
Fall Asleep FasterDeshpande et al. Sleep Med. 2020
Zhdanova et al. Sleep. 1996
Murthy et al. Prev Nutr Food Sci. 2022**
Nakano et al. Funct Foods Health Dis. 2012
Stay AsleepDeshpande et al. Sleep Med. 2020
Zhdanova et al. J Clin Endocrinol Metab. 2001†
Murthy et al. Prev Nutr Food Sci. 2022**
Nakano et al. Funct Foods Health Dis. 2012
Wake Up RefreshedZhdanova et al. Sleep. 1996
Nakano et al. Funct Foods Health Dis. 2012
Healthy Aging OvernightDeshpande et al. Sleep Med. 2020
Nakano et al. Funct Foods Health Dis. 2012
Mishra et al. Heliyon. 2024††
Microbiome BenefitsThomaz et al. J Funct Foods. 2020**
Mi et al. Front Microbiol. 2022**
BenefitStudies
Non-Habit Forming (Bioidentical Dose of Melatonin)Zhdanova et al. Sleep. 1996
Zhdanova et al. J Clin Endocrinol Metab. 2001†
Fall Asleep FasterDeshpande et al. Sleep Med. 2020
Zhdanova et al. Sleep. 1996
Murthy et al. Prev Nutr Food Sci. 2022**
Nakano et al. Funct Foods Health Dis. 2012
Stay AsleepDeshpande et al. Sleep Med. 2020
Zhdanova et al. J Clin Endocrinol Metab. 2001†
Murthy et al. Prev Nutr Food Sci. 2022**
Nakano et al. Funct Foods Health Dis. 2012
Wake Up RefreshedZhdanova et al. Sleep. 1996
Nakano et al. Funct Foods Health Dis. 2012
Healthy Aging OvernightDeshpande et al. Sleep Med. 2020
Nakano et al. Funct Foods Health Dis. 2012
Mishra et al. Heliyon. 2024††
Microbiome BenefitsThomaz et al. J Funct Foods. 2020**
Mi et al. Front Microbiol. 2022**

** Preclinical substantiation
†: In older aged participants (50+ y) with insomnia
††:  In participants with higher stress/anxiety

Testing

Microbiological DataDescriptionUnit of Measure (LOQ)Testing Frequency
Candida albicansAbsent/tabletEvery lot
E. coliAbsent/tabletEvery lot
Pseudomonas aeruginosaAbsent/tabletEvery lot
Staphylococcus aureusAbsent/tabletEvery lot
Yeast and molds≤20 CFU/gEvery lot
Microbiological DataDescriptionUnit of Measure (LOQ)Testing Frequency
Candida albicansAbsent/tabletEvery lot
E. coliAbsent/tabletEvery lot
Pseudomonas aeruginosaAbsent/tabletEvery lot
Staphylococcus aureusAbsent/tabletEvery lot
Yeast and molds≤20 CFU/gEvery lot
Chemical Contaminants
Heavy Metals [Inorganic]		DescriptionUnit of Measure (LOQ)Testing Frequency
Arsenic<0.15 ppm (parts per million)Every lot
Lead<0.50 ppmEvery lot
Cadmium<0.05 ppmEvery lot
Mercury<0.30 ppmEvery lot
Chemical Contaminants
Heavy Metals [Inorganic]		DescriptionUnit of Measure (LOQ)Testing Frequency
Arsenic<0.15 ppm (parts per million)Every lot
Lead<0.5 ppmEvery lot
Cadmium<0.05 ppmEvery lot
Mercury<0.30 ppmEvery lot
Chemical Contaminants
[Organic]		DescriptionTesting Frequency
AMPA (breakdown product of glyphosate)Quarterly
GlyphosateQuarterly
Pesticides/Biocides [500+ different chemicals]Quarterly
DescriptionTesting Frequency
AMPA (breakdown product of glyphosate)Quarterly
GlyphosateQuarterly
Pesticides/Biocides [500+ different chemicals]Quarterly
AllergenUnit of Measure (LOQ)Testing Frequency
Almond<0.1mgQuarterly
Brazil Nut<0.1mgQuarterly
Cashew<0.05mgQuarterly
Celery<0.07mgQuarterly
CornRun and report*Quarterly
Gluten (wheat protein) [across barley, rye, oats + wheat] <20 ppmQuarterly
Crustacean (shrimp protein)<26.2mgQuarterly
Egg<0.2mgQuarterly
Fish<2.6mgQuarterly
Hazelnut<0.1mgQuarterly
Lupin<2.9mgQuarterly
Macadamia Nut<0.1mgQuarterly
Milk<0.2mgQuarterly
MollusksRun and report*Quarterly
Mustard<0.07mgQuarterly
Peanut<0.2mgQuarterly
Pecan<0.03mgQuarterly
Pine Nut<0.1mgQuarterly
Pistachio<0.05mgQuarterly
Sesame<0.1mgQuarterly
Soy<0.5mgQuarterly
Sulfiting Agents<10 ppmQuarterly
Walnut<0.03mgQuarterly
AllergenUnit of Measure (LOQ)Testing Frequency
Almond<0.1mgQuarterly
Brazil Nut<0.1mgQuarterly
Cashew<0.05mgQuarterly
Celery<0.07mgQuarterly
CornRun and report*Quarterly
Gluten [across barley, rye, oats + wheat] (wheat protein)<20 ppmQuarterly
Crustacean (shrimp protein)<26.2mgQuarterly
Egg<0.2mgQuarterly
Fish<2.6mgQuarterly
Hazelnut<0.1mgQuarterly
Lupin<2.9mgQuarterly
Macadamia Nut<0.1mgQuarterly
Milk<0.2mgQuarterly
MolluscsRun and report*Quarterly
Mustard<0.07mgQuarterly
Peanut<0.2mgQuarterly
Pecan<0.03mgQuarterly
Pine Nut<0.1mgQuarterly
Pistachio<0.05mgQuarterly
Sesame<0.1mgQuarterly
Soy<0.5mgQuarterly
Sulfiting Agents<10 ppmQuarterly
Walnut<0.03mgQuarterly

‡Maximum daily doses are clinically-derived from oral food challenge studies and reflect the most recent advancements in food allergy research.  The reference dose, also termed ED01, is the dose at which 1% of the allergic population would be predicted to experience any objective allergic reaction (i.e., 99% of the allergic population does not experience any objectively measurable reaction).

*Inadequate number of clinical studies using low dose oral challenges with this allergen.

Most supplements, fruits, vegetables, milk-derived proteins, and natural products carry some level of heavy metals. These can be very difficult to completely eliminate from the diet, due to their uptake from the surrounding air, water, and soil. In California, food and natural products are regulated under Proposition 65 (the Safe Drinking Water and Toxic Enforcement Act of 1986), which sets ‘safe harbor levels’ for chemicals known to the state to potentially cause cancer or reproductive toxicity.

Seed abides by these stringent regulations and tests all products for the four main categories of heavy metals: Arsenic, Cadmium, Lead, and Mercury.

PM-02™ is tested for over 500 pesticide residues using gas chromatography with tandem mass spectrometry at third-party accredited laboratories. PM-02™ is intentionally subjected to testing for the ubiquitous pesticide, glyphosate, as well as its breakdown product, AminoMethylPhosphonic Acid (AMPA), using liquid chromatography with tandem mass spectrometry. This rigorous testing protocol ensures adherence to our strict quality standards.

The full list of pesticides PM-02™ is tested for may be viewed here.

Interactions

Can I take PM-02™ with other supplements?

PM-02™ is safe to take with other supplements and there are no known contraindications with medications. We recommend consulting your physician about your current prescription medications, so they can advise you with full knowledge of your health history.

Can I take PM-02™ with DS-01®?

Yes, you can take PM-02™ with DS-01®—and they’re a great combination. Each product supports a different, but complementary part of your health.

PM-02™ is formulated to support deep, restorative sleep by helping regulate cortisol levels in the evening and delivering bioidentical melatonin to align with your body’s natural sleep cycle. It’s designed to help you wind down, fall asleep more easily, and wake up feeling refreshed.*

DS-01® is a broad-spectrum synbiotic formulated with clinically studied probiotic strains to improve your gut microbiome and support whole-body health—including digestion, skin, heart, immunity, and the gut-brain axis.*

Together, they offer more complete support for you to stay balanced and resilient: PM-02™ helps your body recover and reset while you sleep, and DS-01® supports your gut microbiome, the foundation of your health, which plays a key role in everything from digestion, to immune balance, to skin health.*

Can I take PM-02™ with other sleep supplements?

We don’t recommend combining PM-02™ with other products containing melatonin or sleep supplements like magnesium, CBD, or herbal aids, unless directed by your healthcare provider. PM-02™ already includes a research-informed dose that may lead to grogginess or disrupted sleep if exceeded.

While PM-02™ has no known contraindications with supplements like magnesium, valerian root, chamomile, or CBD, individual responses can vary, so it’s best to consult your personal physician before using additional sleep aids.