Skip to main content

VS-01™
Vaginal Synbiotic

The first vaginal probiotic suppository clinically validated to establish an optimal vaginal microbiome dominated by L. crispatus.

$99.00
2 Month Starter Kit
$39.99/month thereafter
    While we work on expanding access to VS-01™ beyond the US, we invite you to join our international waitlist to be among the first to receive updates on its release in your region. Join our  to be notified.

Day-to-day life can disrupt the balance of your vaginal microbiome, depleting its critical super defender—Lactobacillus crispatus.

Menstruation

Diet

Stress

Past Pregnancy

Exercise

Swimming

Sex

Sex Toys

Condom Use

Oral Sex

Gels and Lubricants

Certain Contraceptives

Certain Prescriptions

Certain Cleansers

Feminine Hygiene Products

VS-01™ Vaginal Synbiotic

What Is the Vaginal Microbiome?

Comprised of bacteria, fungi, and viruses, this ecosystem is critical to your gynecological, urogenital, and reproductive health. Unlike the diverse gut microbiome, the vaginal microbiome thrives when dominated by one bacterium: L. crispatus.

However, many lack this abundance, leading to susceptibility to disruptions and imbalances.

9 out of 10 women have an unstable vaginal microbiome.1

Proportion of Subjects by Stability
graph showing 90% of women have an unstable vaginal microbiome
% of Subjects
Figure 1. The proportion of participants who underwent daily sampling and had a stability score equal to or greater than 90%. Only 10% of participants exhibited a stable vaginal microbiome. Stability score was defined as the proportion of days in which an individual had an L. crispatus dominated microbiome.

Citations

1 Seed Health R+D (2024) Disruption and Stability of the Vaginal Microbiome: A Data-Driven Approach [White Paper] Seed Health.

BUILT ON DR. JACQUES RAVEL’S RESEARCH

VS-01™ emerged from the discovery that specific strains of L. crispatus  defend the vaginal microbiome from pH disruptions and imbalances.
L. crispatus
Fig 1. Our three proprietary L. crispatus strains in VS-01™.
VS-01™ Vaginal Synbiotic
A Victory for Vaginal Health
Propelled by the unmet needs in women’s health, we partnered with Dr. Jacques Ravel to transform over two decades of vaginal microbiome sampling and metagenomic research into real world impact.
Jacques Ravel, PhD
Jacques Ravel, PhD
Seed Scientific Advisor
Founder, LUCA Platform
2006
Dr. Ravel receives the first-ever NIH grant dedicated to studying the vaginal microbiome.
2009
Dr Ravel initiates the vaginal program under the NIH’s Human Microbiome Project (HMP) to define what constitutes a healthy vaginal microbiome.
2012
Dr. Ravel publishes a landmark study1 demonstrating that the most stable and optimal vaginal microbiome is dominated by one bacterium: Lactobacillus crispatus.
2016-Present
Seed partners with Dr. Ravel to launch LUCA Biologics, a vaginal microbiome platform targeting the vaginal microbiome for unmet needs in gynecological and reproductive health.
2020
Dr. Ravel publishes the largest metagenomic gene catalog2 of the vaginal microbiome to date.
2023
Dr. Ravel publishes the most comprehensive metagenomic analysis3 characterizing the vaginal microbiome into 27 community state types, including 6 sub-types of L. crispatus.
Today
VS-01™ is the first innovation to emerge from Seed's vaginal microbiome platform, setting a new paradigm of innovation, empowerment, and care.
CITATIONS
1 Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J., Schütte, U. M., Zhong, X., Koenig, S. S., Fu, L., Ma, Z. S., Zhou, X., Abdo, Z., Forney, L. J., & Ravel, J. (2012). Temporal dynamics of the human vaginal microbiota. Science Translational Medicine, 4(132), 132ra52. https://doi.org/10.1126/scitranslmed.3003605
2 Brouillett, Monique. Scientific American. 2020. Decoding the Vaginal Microbiome. Retrieved May 4, 2024, from https://www.scientificamerican.com/article/decoding-the-vaginal-microbiome/
3 Holm, J.B., France, M.T., Gajer, P. et al. Integrating compositional and functional content to describe vaginal microbiomes in health and disease. Microbiome 11, 259 (2023).
https://doi.org/10.1186/s40168-023-01692-x

An Evolution in Vaginal Health

VS-01™ is the first and only vaginal synbiotic clinically validated to optimize your vaginal microbiome with three proprietary L. crispatus probiotic strains.

Three proprietary live L. crispatus probiotic strains selected for their genomic diversity and strengthening of vaginal stability and resilience: LUCA103™, LUCA011™, LUCA009™.
Loading thumbnail for video
VS-01™ Vaginal Synbiotic

Formulation

L. crispatus LUCA103™, L. crispatus LUCA011™, L. crispatus LUCA009™
Maltose, Calcium Lactate, Glutamine, DiBasic Magnesium Citrate, Cystine
Plant-Derived Cellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose (HPMC)
Tested for biocompatibility with the vaginal environment, 14 classes of allergens, 500+ contaminants, and osmolality.
Non-Irritating icon
Non-Irritating
Non-Toxic icon
Non-Toxic
No PFAS icon
No PFAS
No Preservatives or Parabens icon
No Preservatives or Parabens
No BPAs icon
No BPAs
No Phthalates icon
No Phthalates
Vegan icon
Vegan
No Artificial Fragrances or Dyes icon
No Artificial Fragrances or Dyes

VS-01™ requires your body’s natural lubrication for proper dissolution, and therefore may not be as effective among women experiencing significant vaginal dryness.

CLINICALLY VALIDATED EFFICACY

Results from a randomized, double-blind, placebo-controlled clinical trial:
90%
Of participants established an optimal vaginal microbiome dominated by L. crispatus
10x
Increase of L. crispatus abundance in participants within 21 days of use
100%
Of participants maintained an optimal vaginal pH
VS-01™ Vaginal Synbiotic
Our Clinical Research

In our first randomized, double-blind, placebo-controlled clinical trial, VS-01™ converted 90% of participants to an optimal vaginal microbiome within 21 days and was superior to both a leading oral probiotic for vaginal health and placebo1.


Graph showing proportion of converters to optimal vaginal microbiome at 21 days
Figure 1. The proportion of participants with a non-optimal baseline vaginal microbiome who converted to an optimal vaginal microbiome.
Graph showing change in average relative abundance of Lactobacillus crispatus
Figure 2. Change in the average relative abundance of L. crispatus in participants with a non-optimal baseline vaginal microbiome.
CITATIONS
1 Ravel, J., Simmons, S.,  Greenwood Jawa, E., Gottfried, S., Greene, M., Kellogg-Spadt, S., Gevers, D., Harper, D. IDSOG Annual Meeting 2024.

Using VS-01™

Address the Source, Not the Symptoms

Finally, a sustainable approach to address the root cause of imbalances and sustainably defend against daily disruptions.

VS-01 Open Reset Box with Closed Sustain Box and Applicator

2 Month Starter Kit

Month 1 Reset

Your first-month reset to rapidly establish an optimal vaginal microbiome.

VS-01 Open Reset Box

Month 2+ Sustain

The two-tablet monthly protocol that maintains stability and protects against pH disruptors.

VS-01 Open Sustain Box
"Since starting VS-01™, I’m not as worried about the potential of disrupting my vagina."
"I noticed results in a few weeks of use, with more significant results after 1 month of use."
"For me, it was more about not noticing things that were common and disruptive to my day. I was having to put a lot of unnecessary attention to those things before."
"Sometime during the first week, I realized I was no longer aware of my vagina. Which sounds funny, but not noticing my vagina was actually amazing."

A New Standard of Safety

The vagina is one of the most delicate ecosystems of the human body, yet vaginal health products are not subject to rigorous safety testing. We set out to close the gap with superior testing and safety checks.

  • Biocompatibility with the vaginal environment
  • 14 classes of allergens, including gluten, nuts, and soy
  • 500+ contaminants (chemical residues and heavy metals)
  • Osmolality (typically only tested for in lubricants)
  • Non-disruptive to the vaginal mucosal barrier in a cruelty-free, FDA-recognized tissue model
  • No histological changes or cellular tissue damage
  • No adverse toxicity outcomes in gold-standard human clinical trial
Non-Irritating icon
Non-Irritating
Non-Toxic icon
Non-Toxic
No PFAS icon
No PFAS
No Preservatives or Parabens icon
No Preservatives or Parabens
No BPAs icon
No BPAs
No Phthalates icon
No Phthalates
No Artificial Fragrances or Dyes icon
No Artificial Fragrances or Dyes
Vegan icon
Vegan

VS-01™ requires your body’s natural lubrication for proper dissolution, and therefore may not be as effective among women experiencing significant vaginal dryness.

From Leading Providers

Erica Chidi
Erica Chidi
Author, Health Educator and Entrepreneur
“VS-01™ represents a tectonic shift in women's health. It's the missing link in how women can protect and maintain their vaginal health, backed by rigorous science.”
Jane van Dis
Jane van Dis, MD
Assistant Professor of Obstetrics & Gynecology, University of Rochester
“VS-01™ offers a way out of the endless cycle of symptom management, providing a means to maintain the health of the vaginal microbiome against everyday disruptors. This is more than a product; it’s a paradigm shift in how we think about and care for vaginal health.”
The VS-01™ Difference
Many existing products and certain prescriptions for vaginal health only target the symptoms and can disrupt the vaginal microbiome. VS-01™ offers a new approach that outperforms on efficacy and safety.
VS-01™Leading Oral Probiotic for Vaginal HealthCertain Prescriptions
Establishes an optimal, resilient vaginal microbiome
Increases abundance of L. crispatus
Safely interacts directly with epithelial cells in the vagina
View All

Expanding Impact and Access

Women's health has been neglected for far too long. Inadequate funding and research have stifled innovation and left critical gaps in care.

While VS-01™ marks an exciting milestone in our effort to prioritize vaginal microbiome research and address the unmet needs of people with vaginas, we believe there is much more to be done when it comes to democratizing safe and effective care. Here are a few ways we're working to improve access:

You can purchase VS-01™ using your HSA or FSA debit card at checkout. Check with your plan administrator as specific approval may vary by carrier.
More programs and education are on the way. If you know of a nonprofit organization or healthcare provider interested in collaborating, email impact@seed.com .
We recognize that the definition of women's health is evolving. To ensure inclusivity in our language, imagery, and marketing, we have partnered with the  Eidos LGBTQ+ Health Initiative at the University of Pennsylvania.
Hand holding VS-01 tablet

Meet SciCare

Skip the searches—our team of experts is here to answer your questions about the vaginal microbiome, VS-01™, and beyond.

Hi, I’m Jordie from SciCare. I’m happy to answer any of your VS-01™ questions.
How can I help you?

Questions? We're here to guide you.

We keep a list of questions we get asked often on our FAQ page.

If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We’ll refund you for the full cost of the product less shipping, VAT, and duties—no questions asked. Refunds apply to your first order only, not any subsequent shipments. For all subsequent shipments, you may reschedule or cancel at any time in your Account.

Kindly note that Sustainable Refill Program orders are considered final sale 30 days after delivery.

While most available solutions target only the symptoms in ways that further disturb the vagina, VS-01™ addresses the source—the vaginal microbiome. VS-01™ begins with an intensive first month Reset to rapidly establish an optimal vaginal microbiome and continues with monthly Sustain — the simple, two-tablet monthly protocol to maintain a stable vaginal microbiome and regulate pH. 

In a double-blind, randomized, placebo-controlled clinical trial, VS-01™ restored and maintained an optimal vaginal microbiome 10x more effectively than a leading oral vaginal probiotic, and 100% of participants experienced regulated vaginal pH.

VS-01™ is designed for ongoing use to rapidly establish and then maintain a resilient vaginal microbiome less prone to disruptions from day-to-day life. VS-01™ is also rigorously third-party evaluated and verified safe for long-term use.

VS-01™ is recommended for individuals 18 and older seeking to restore and maintain an optimal vaginal microbiome.

VS-01™ has been clinically studied among individuals 18-55 years old, and clinicians have used it through all adult ages. If you have any pre-existing conditions and are curious about incorporating VS-01™ into your routine, please consult with your health care provider.

VS-01™ has a rigorous safety profile through clinical (in humans) and preclinical (in laboratory environments) testing. VS-01™ is extensively third-party evaluated for contaminants, heavy metals, impurities and all classes of allergens. It is formulated with gentle, non-irritating ingredients and tested for safety and vaginal biocompatibility using an FDA-recognized tissue model.

You can place an order online using your FSA or HSA card (as you would any other credit or debit card). We’ve taken all of the necessary steps on our end to ensure that you can use your FSA or HSA funds to purchase VS-01™. We also recommend consulting your provider to determine what documentation is required to have your claim approved, as many providers require a Letter of Medical Necessity (LMN) in addition to a receipt.

Your monthly subscription includes a 30-day supply of PDS-08®, each dose housed in biofilm sachets. Your first month’s shipment is your Welcome Kit. It includes a refillable aluminum BacTrac™ container holding the first month’s supply of PDS-08® as well as some reading materials.

Each month, you will receive a 30-day supply of PDS-08®, which you can store in your refillable BacTrac™.

Menstruation is one of the most known day-to-day disruptors of the vaginal microbiome. VS-01™ is designed to work with your body’s unique cycle by rapidly restoring your vaginal microbiome with an initial Reset, and then maintaining stability and regulated pH with monthly use.

Gently press a VS-01™ vaginal tablet out of the aluminum pack into washed hands before each use. Place the VS-01™ vaginal tablet securely into an applicator. Insert into your vagina, and push the inner tube towards you to release (just like a tampon). After releasing, remove and dispose of the applicator. Please note that each applicator is a Class I Medical Device and cannot be recycled.

Yes—you can be sexually active while using VS-01™, though we recommend abstaining from sexual activity for 12 hours after inserting a tablet, to allow the tablet enough time to dissolve completely.

Overall rating: 4.667411 / 5 from 448 reviews.

AI Generated Review Summary

VS-01™ Vaginal Synbiotic is highly recommended by customers for relieving frequent UTIs and improving vaginal health. Users appreciated its ability to reset and regulate the microbiome, reduce recurring infections, and enhance overall comfort and confidence.

Summary topics

  • UTI Relief (4%): It was reported by customers that VS-01 was highly recommended for relieving frequent UTIs.
  • Infection Reduction (3%): Customers appreciated the product for its ability to improve the microbiome and reduce recurring infections in the vagina.
  • Noticeable Difference (11%): Customers appreciated the noticeable difference in comfort levels and urinary health after using Seed's vaginal Synbiotic.
  • Healthier Feeling (5%): Customers expressed satisfaction with the VS-01 product, stating that it made them feel healthier and more confident about their bodies.
  • Microbiome Regulation (4%): It was noted by customers that the VS-1 Synbiotic reset and regulated their microbiome perfectly.

Review topics: ["smell","feel","packaging","issues","symptoms","improvement","irritation","difference","results","impact","balance","probiotic","relief","discomfort","pain","seed","customer service","comfort","yeast infections","microbiome","vs-01","antibiotics","works","life","bacteria","use","uti","change","health","infection"].

Review highlights

  • "My doctors gave me oral probiotics, antibiotics, antifungals, and estrogen cream." — Lori P.
  • "5), my cycle feels more balanced, and even during my period there’s no odor at all." — Amber J.
  • "Has made a big difference - no longer have uncomfortable episodes that popped up infrequently prior to starting" — Katherine C.

Reviews

Item works well. However, I

"Item works well. However, I cancelled my subscription a long time ago and just was charged and sent the order anyway. Not happy about this, and having to figure out how to not have this happen again. I wish seed products were still available as needed. It’s got the worst kind of capitalist vibes to force people subscribe for healthcare products because that’s the only way to get them."

— Eleni M. (4/5)

This has really helped with

"This has really helped with the reoccurring yeast infections I was having"

— Heather D. (5/5)

I like the three month

"I like the three month sustain in one pack. Wouldn’t change a thing about formula, would love to see more discounts especially if you buy a lot over time"

— Katie N. (5/5)

This has saved my life.

"This has saved my life. I was so depressed about all of my "issues" and how nothing ever resolved them. Antibiotics, no. Antifungals, no. Probiotic pills, no. Boric acid, no. I tried everything to no avail, until Seed. This product WORKS!!!!! I no longer have any issues and I feel normal again for the first time in years. THANK YOU SEED FOR PROVIDING HEALTHCARE SOLUTIONS THAT ACTUALLY SOLVE THE PROBLEM!!!!!!!!!!"

— Patricia A. (5/5)

Using this for months along

"Using this for months along side diet changes and supplements has helped me beat chronic yeast infections!! TMI but my first few months using I’d see the yeast being expelled by the good bacteria. Now I no longer see that so I’m happy to say it’s keeping me balanced!"

— Samantha F. (5/5)

I've been meaning to write

"I've been meaning to write a review because this product has dramatically improved my life! I suffered from recurrent yeast infections and tried everything the specialists could offer. They basically gave up on me and said I'd just need to use Monistat every week prophylactically. This vaginal probiotic finally helped me wean off that protocol! I do keep using it to maintain a healthy vaginal biome. I actually prefer to use half a tablet every week and everything is just peachy down there. My most sincere thanks to Seed for this product."

— Angela F. (5/5)

Love this product. Easy to

"Love this product. Easy to use. Definitely has improved my overall vaginal health."

— Erin L. (5/5)

This product is 5 stars!

"This product is 5 stars! Wish I had this when I was a teenager when I started having problems. I feel so much better and much more confident. Don’t hesitate like I did and wait, get it now."

— Chloe C. (5/5)

Works well. Recommend it

"Works well. Recommend it"

— Star C. (5/5)

VS-01 is easy to use

"VS-01 is easy to use and has helped with lubrication, as I hoped. The well-designed packaging is impressive, too!"

— Marcia P. (5/5)

Q&A