Science

The New Biology

The microbiome marks an evolution of health–both within and beyond our bodies. New technologies and research inform that each one of us is a vast and complex ecosystem. This new biology reveals the potential of bacteria to restore and sustain the systemic health of ourselves and our environment, radically transforming our approach to medicine, hygiene, diet, and living.
We’re Seed—an ecosystem of scientists, doctors, innovators, thinkers, and translational storytellers, pioneering the inquiry and application of microbiome science to improve human and planetary health.

It takes a brainforest.

Our Scientific Advisory Board is comprised of scientists, researchers, doctors, and authors across the fields of microbiology, immunology, genetics, metabolomics, gastroenterology, pediatrics, molecular biology, and transcriptomics—including primary investigators from the NIH’s Human Microbiome Project. They lead labs, teach at world-renowned academic institutions, and have among them 2800+ publications and over 140,000 citations in peer-reviewed scientific journals and textbooks.

Scientific Advisory Board

Dr. Jacques Ravel PhD

Dr. George Church PhD

Dr. James Versalovic MD, PhD

Dr. Joseph Petrosino PhD

Dr. Janet Jansson PhD

Dr. Martin Blaser MD

Dr. Belinda Tan MD, PhD

Dr. John Ryals PhD

Dr. Geoffrey Preidis MD, PhD

Dr. Shruti Naik PhD

Chief Scientist

Dr. Gregor Reid PhD, MBA

The Seed Platform

Technology

Our platform includes Simulator of the Human Intestinal Microbial Ecosystem (SHIME), flow cytometry, whole genome sequencing, untargeted metabolomics, and a proprietary screening platform to isolate mechanistic pathways in a host model built on intellectual property exclusively licensed from The Department of Genetics at Harvard Medical School.

Probiotic Strain Bank

Our strain collection includes probiotic strains banked in Italy, Denmark, United Kingdom, France, Belgium, Spain, Japan, and the United States. Our collection of strains, methods of use, finished formulations, and scale-up processes are unique to Seed and not found in yoghurt, fermented foods, or ‘probiotic’ beverages.

All of our strains have GRAS and/or QPS (Qualified Presumption of Safety) status under the European Food and Safety Authority (EFSA). They are not cultured with, and are free from the 12 Classes of Allergens defined in Annex IIIa of Directive 2007/68/EC.Directive 2007/68/EC.

Biofermentation / Microbial Stabilization

Every microbe has its own preferred growth medium and ideal fermentation parameters for maximum viability as a probiotic. Our bacteria are biofermented in conditions optimized for pH, temperature, oxygen, water activity, and 26 other growth factors. Our mediums do not contain meat or dairy. Biofermentation of all strains are conducted under cGMP and HACCP guidelines.

Testing

Our mechanistic research includes human cell line testing (Caco-2), in vitro research (TEER test), short-chain fatty acid testing, gastrointestinal transit assays measuring resistance to biological substances (stomach acid, primary bile salts, secondary bile salts, digestive enzymes), and a genomic pathway model evaluating oxidative stress and anti-inflammatory effects on specific pathways (Nrf2) in the human body.

Clinical Work

To date, our strains have collectively been studied in 23 human clinical studies including double-blind, placebo-controlled trials conducted in the United States, United Kingdom, Italy, Spain, and Japan. Primary and secondary outcomes demonstrate statistically significant improvements in multiple markers of gastrointestinal health, cardiovascular health, and dermatological health. These studies are published in peer-reviewed journals like Journal of Clinical Gastroenterology, Scientific Reports (Nature), and JAMA Dermatology, and are all indexed to PubMed, the central database for life science journal literature at the National Institute of Health.

A pipeline for the whole-body biome.

Through exclusive partnerships, academic collaborations, and strategic joint-ventures, we’re developing a pipeline of consumer probiotics and live biotherapeutics to target specific body sites and life stages in which the microbiome impacts human health.

Consumer Probiotics

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Cardiovascular Health

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Dermatological Health

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Infant Health

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Metabolic

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Nutrition

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Oral

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Prenatal

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Vaginal Health

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Science isn't static—there are 65071 publications on PubMed around the microbiome, probiotics, and prebiotics (and counting).

While we won’t hyperbolize where the science is today, we do believe microbiome research has a promising future. We work closely with our braintrust to ensure our pipeline and communications reflect our commitment to precision, accountability, and efficacy.

Earth to Science

Science has a communication problem.
It can feel cold and complicated,
yet the warm and simple often misinform.

We believe the translation of science is foundational to human health. Awakening your inner scientist leads to better questions, better choices, and better health.

Curiosity is rewarded—
Free knowledge for your world within.
Wonderful. We'll be in touch.
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