Reference

DS-01™ Daily Synbiotic

DS-01™ Daily Synbiotic
Overview
Formulation
Directions for Use
Clinical Trials
Strain-Specific Benefit Studies
Testing
Interactions
Reference Library
Overview
Formulation
Directions for Use
Clinical Trials
Strain-Specific Benefit Studies
Testing
Interactions

DS-01™ comprises 24 scientifically validated probiotic strains with a patented, non-fermenting prebiotic. This breakthrough formulation is paired with innovations in probiotic stabilization and a precision-release system to deliver strains to the lower small intestine to support systemic benefits, including digestive, heart, skin, and gut health.

Formulation

Digestive Health / Gut Immunity / Gut Barrier Integrity Probiotic Blend

37.0 Billion AFU

Bifidobacterium breve SD-BR3-IT

Bifidobacterium longum SD-BB536-JP

Bifidobacterium infantis SD-M63-JP

Bifidobacterium lactis HRVD524-US (Bl-04)

Bifidobacterium breve HRVD521-US

Bifidobacterium longum HRVD90b-US

Bifidobacterium lactis SD150-BE

Bifidobacterium longum SD-CECT7347-SP

Lactiplantibacillus plantarum SD-LP1-IT         

Limosilactobacillus reuteri RD830-FR

Limosilactobacillus fermentum SD-LF8-IT

Lacticaseibacillus rhamnosus HRVD113-US

Lacticaseibacillus casei HRVD300-US

Lacticaseibacillus rhamnosus SD-GG-BE

Lacticaseibacillus rhamnosus SD-LR6-IT

Ligilactobacillus salivarius SD-LS1-IT

Dermatological Health Probiotic Blend

3.3 Billion AFU

Bifidobacterium longum SD-CECT7347-SP

Bifidobacterium lactis SD-CECT8145-SP

Lacticaseibacillus casei SD-CECT9104-SP

Ligilactobacillus salivarius SD-LS1-IT

Cardiovascular Health Probiotic Blend

5.25 Billion AFU

Bifidobacterium lactis SD-MB2409-IT

Lactiplantibacillus plantarum SD-LPLDL-UK

Micronutrient Synthesis Probiotic Blend

8.05 Billion AFU

Bifidobacterium adolescentis SD-BA5-IT (DSM18352)

Limosilactobacillus reuteri SD-LRE2-IT 

Microbiota-Accessible Polyphenolic Precursors™ [MAPP] 400mg

400mg

Indian Pomegranate [whole fruit] (Punica granatum) (>40% Polyphenolic + Phenolic Bioactives)

Directions for Use

Take 1 capsule daily for the first three days.

On day four (or when you’re ready), increase to the full dose of 2 capsules—at once—daily. Ideally, take both capsules on an empty stomach at least 10 minutes prior to a meal, or on an empty stomach prior to sleeping.

image-acclimation-protocol-large
Fig. 1 — Acclimation protocol
image-acclimation-protocol-small
Fig. 1 — Acclimation protocol

Adults—take 2 capsules—at once—daily. Ideally, take both capsules on an empty stomach at least 10 minutes prior to a meal, or on an empty stomach prior to sleeping. If any discomfort persists past Day 14, you may try taking DS-01™ immediately following a meal. No refrigeration necessary. Store in a cool, dry place. Stable for 18 months.

Just as with any new diet, product, or change, you may experience a temporary acclimation period—some gastrointestinal discomfort, abdominal tightness, mild nausea, or changes in your stool. This is normal.

In fact, an immediate physiological reaction is a sign that our probiotics are viable and attuning to your system. Any discomfort should subside within the first one to two weeks.

Clinical Trials

DS-01™ in Irritable Bowel Syndrome (IBS)

The objective of this placebo-controlled study is to assess the effect of the 24-strain Daily Synbiotic (SH-DS01) on the composition and metabolism of the intestinal microbiota as well as to evaluate a range of IBS symptoms in a cohort of 100 subjects with constipation—predominant (IBS-C) or mixed (IBS-M) irritable bowel syndrome. This study will be conducted under an Investigational New Drug application, as authorized by the US Food and Drug Administration. This is a requirement for testing dietary supplements among persons with chronic conditions or diseases.

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is commonly seen in clinical practice. Specifically, it is a functional bowel disorder that is thought to result from a disorder of the gut–brain interaction. Though patients with IBS often have a heterogeneous symptom profile, the predominant theme is the presence of abdominal pain or discomfort that is usually relieved by defecation. Genetic background and environmental factors are important for the pathogenesis of IBS, but the precise cause of IBS is still unknown. The long-term goal of our study is to assess the functional impact of probiotics in subjects who suffer from gastrointestinal symptoms and have been diagnosed with IBS-C or IBS-M. Thus far, few studies have been conducted to objectively assess the impact of ingesting live microorganisms on the symptoms of IBS-C or IBS-M such as gas / bloating.

This protocol aims to assess the impact of a mix of 24-beneficial strains on individual gastrointestinal symptoms in a cohort of subjects with IBS-C or IBS-M. The design of this protocol is unique, as we are not only collecting urine, blood, and fecal tissue to assess mechanism of action, but we will also ask the subjects recruited to use a smartphone application to report day-to-day gastrointestinal symptoms such as bloating. This trial is being conducted at Harvard’s Beth Israel Deaconess Medical Center, and began recruitment in 2020.

Impact of DS-01™ on Post-Antibiotic Recovery

The objective of this study is to assess the effect of SH-DS01 on the gut microbiota of healthy adults after taking a course of broad-spectrum antibiotics.

In the United States, healthcare providers prescribe over 270 million antibiotic courses each year. While antibiotics have transformed medicine and methods of treating life-threatening bacterial infection, broad spectrum antibiotics also induce disruption of resident gut microbial communities by altering both composition and function. This disruption of microbial community dynamics has been demonstrated at the taxonomic level, yet the extent of functional disruptions to microbial metabolic output and host cells remains understudied in humans. This study explores the impact of a broad spectrum antibiotic cocktail on microbial communities throughout the gastrointestinal tract, and the rescue effects of a defined, multi-strain consortia of probiotic organisms following antibiotic exposure. This trial began recruitment in Q3 2020.

Strain-Specific Benefit Studies

BenefitStudies
Digestive HealthDel Piano et al. J Clin Gastroenterol. 2010Mogna et al. J Clin Gastroenterol. 2012Ogata et al. Biosci Microflora. 1997Thongaram et al. J Dairy Sci. 2017Ma et al. Benef Microbes. 2019
Gut Barrier IntegrityLong Yan Fong et al. J Funct Foods. 2015
Gut Immune FunctionMogna et al. J Clin Gastroenterol. 2012Lau et al. Benef Microbes. 2018Odamaki et al. Anaerobe. 2012Xiao et al. J Investig Allergol Clin Immunol. 2006West et al. Clin Nutr, 2014Turner et al. Benef Microbes. 2017Drago et al. llergy Asthma Immunol Res. 2015Magistrelli et al. Front Immunol. 2019Olivares et al. J Agric Food Chem. 2011Medina et al. J Inflammation. 2008De Palma et al. J Leukoc Biol. 2012Laparra & Sanz. J Cell Biochem. 2010
Cardiovascular HealthCostabile et al. PLoS One. 2017Bordoni et al. Appl Microbiol Biotechnol. 2013Ameretti et al., Appl Microbiol Biotechnol. 2013
Dermatological HealthIemoli et al. J Clin Gastroenterol. 2012Reddel et al. Sci Rep. 2019Drago et al. Int J Immunopathol Pharmacol. 2011Niccoli et al. J Clin Gastroenterol. 2014Drago et al. J Clin Gastroenterol. 2012Navarro-López et al. JAMA Dermatol. 2018
Micronutrient SynthesisMogna et al. J Clin Gastroenterol. 2014Strozzi & Mogna. J Clin Gastroenterol. 2008Pompei et al., Appl Environ Microbiol. 2007
BenefitStudies
Digestive HealthDel Piano et al. J Clin Gastroenterol. 2010Mogna et al. J Clin Gastroenterol. 2012Ogata et al. Biosci Microflora. 1997Thongaram et al. J Dairy Sci. 2017Ma et al. Benef Microbes. 2019
Gut Barrier IntegrityLong Yan Fong et al. J Funct Foods. 2015
Gut Immune FunctionMogna et al. J Clin Gastroenterol. 2012Lau et al. Benef Microbes. 2018Odamaki et al. Anaerobe. 2012Xiao et al. J Investig Allergol Clin Immunol. 2006West et al. Clin Nutr, 2014Turner et al. Benef Microbes. 2017Drago et al. llergy Asthma Immunol Res. 2015Magistrelli et al. Front Immunol. 2019Olivares et al. J Agric Food Chem. 2011Medina et al. J Inflammation. 2008De Palma et al. J Leukoc Biol. 2012Laparra & Sanz. J Cell Biochem. 2010
Cardiovascular HealthCostabile et al. PLoS One. 2017Bordoni et al. Appl Microbiol Biotechnol. 2013Ameretti et al., Appl Microbiol Biotechnol. 2013
Dermatological HealthIemoli et al. J Clin Gastroenterol. 2012Reddel et al. Sci Rep. 2019Drago et al. Int J Immunopathol Pharmacol. 2011Niccoli et al. J Clin Gastroenterol. 2014Drago et al. J Clin Gastroenterol. 2012Navarro-López et al. JAMA Dermatol. 2018
Micronutrient SynthesisMogna et al. J Clin Gastroenterol. 2014Strozzi & Mogna. J Clin Gastroenterol. 2008Pompei et al., Appl Environ Microbiol. 2007
Fig. 4 — Strain microscopy: 1 <i>Lactobacillus rhamnosus</i> SD-LR6-IT, 2 <i>Lactobacillus plantarum</i> SD-LPLDL-UK, 3 <i>Bifidobacterium longum</i> SD-CECT7347-SP
1
Fig. 4 — Strain microscopy: 1 <i>Lactobacillus rhamnosus</i> SD-LR6-IT, 2 <i>Lactobacillus plantarum</i> SD-LPLDL-UK, 3 <i>Bifidobacterium longum</i> SD-CECT7347-SP
2
Fig. 4 — Strain microscopy: 1 <i>Lactobacillus rhamnosus</i> SD-LR6-IT, 2 <i>Lactobacillus plantarum</i> SD-LPLDL-UK, 3 <i>Bifidobacterium longum</i> SD-CECT7347-SP
3
Fig. 4 — Strain microscopy: 1 Lactobacillus rhamnosus SD-LR6-IT, 2 Lactobacillus plantarum SD-LPLDL-UK, 3 Bifidobacterium longum SD-CECT7347-SP

Testing

Quality Control Testing Battery

Microbiological Data
Microbiological DataDescriptionUnit of Measure (LOQ)Testing Frequency
Yeasts and molds<100 CFU/gEach batch
Enterobacteria<10 MPN/gEach batch
Total coliforms<3 MPN/gEach batch
E. coliAbsent/ 10 gEach batch
SalmonellaAbsent/ 25 gEach batch
Staphylococcus coagulase positive<10 CFU/gEach batch
Listeria monocytogenesNegative/ 25 gEach batch
DescriptionUnit of Measure (LOQ)Testing Frequency
Yeasts and molds<100 CFU/gEach batch
Enterobacteria<10 MPN/gEach batch
Total coliforms<3 MPN/gEach batch
E. coliAbsent/ 10 gEach batch
SalmonellaAbsent/ 25 gEach batch
Staphylococcus coagulase positive<10 CFU/gEach batch
Listeria monocytogenesNegative/ 25 gEach batch
Probiotic Potency
Probiotic PotencyDescriptionUnit of Measure (LOQ)Testing Frequency
All Seed DS-01™ strainsAFU/g (Active Fluorescent Units)Each batch
DescriptionUnit of Measure (LOQ)Testing Frequency
All Seed Daily Synbiotic strainsAFU/g (Active Fluorescent Units)Each batch
Chemical Contaminants
Heavy Metals [Inorganic]
Chemical Contaminants
Heavy Metals [Inorganic]
DescriptionUnit of Measure (LOQ)Testing Frequency
Arsenic<1 ppm (parts per million)Each batch
Lead<3.0 ppmEach batch
Cadmium<1.0 ppmEach batch
Mercury<0.10 ppmEach batch
DescriptionUnit of Measure (LOQ)Testing Frequency
Arsenic<1 ppm (parts per million)Each batch
Lead<3.0 ppmEach batch
Cadmium<1.0 ppmEach batch
Mercury<0.10 ppmEach batch
Chemical Contaminants
[Organic]
Chemical Contaminants
[Organic]
DescriptionUnit of Measure (LOQ)Testing Frequency
AMPA (breakdown product of glyphosate)<10.0 ng/gQuarterly
Glyphosate<10.0 ng/gQuarterly
Pesticides/Biocides [427 different chemicals]Varies; see Pesticides List in Appendix Section IIIQuarterly
DescriptionUnit of Measure (LOQ)Testing Frequency
AMPA (breakdown product of glyphosate)<10.0 ng/gQuarterly
Glyphosate<10.0 ng/gQuarterly
Pesticides/Biocides [427 different chemicals]Varies; see Pesticides List in Appendix Section IIIQuarterly
Allergens
AllergensDescriptionUnit of Measure (LOQ)Testing Frequency
Almond<2.5 ppm (parts per million)Quarterly
Brazil NutNegativeQuarterly
Crustaceans<0.05 ppmQuarterly
Egg<2.5 ppmQuarterly
FishNegativeQuarterly
Gluten [across barley, rye, oats + wheat]<5.0 ppmQuarterly
Macadamia NutNegativeQuarterly
Milk<2.5 ppmQuarterly
PeanutNegativeQuarterly
PecanNegativeQuarterly
PistachioNegativeQuarterly
Soy<2.5 ppmQuarterly
Walnut<2.4 ppmQuarterly
Hazelnuts<2.5 ppmQuarterly
CashewsNegativeQuarterly
Pine Nuts<1.0 ppmQuarterly
CeleryNegativeQuarterly
Mustard<1.0 ppmQuarterly
Sesame Seeds<2.5 ppmQuarterly
Sulphite<8.0 ppmQuarterly
Lupin<1.0 ppmQuarterly
CornNegativeQuarterly
MollusksNegativeQuarterly
DescriptionUnit of Measure (LOQ)Testing Frequency
Almond<2.5 ppm (parts per million)Quarterly
Brazil NutNegativeQuarterly
Crustaceans<0.05 ppmQuarterly
Egg<2.5 ppmQuarterly
FishNegativeQuarterly
Gluten [across barley, rye, oats + wheat]<5.0 ppmQuarterly
Macadamia NutNegativeQuarterly
Milk<2.5 ppmQuarterly
PeanutNegativeQuarterly
PecanNegativeQuarterly
PistachioNegativeQuarterly
Soy<2.5 ppmQuarterly
Walnut<2.4 ppmQuarterly
Hazelnuts<2.5 ppmQuarterly
CashewsNegativeQuarterly
Pine Nuts<1.0 ppmQuarterly
CeleryNegativeQuarterly
Mustard<1.0 ppmQuarterly
Sesame Seeds<2.5 ppmQuarterly
Sulphite<8.0 ppmQuarterly
Lupin<1.0 ppmQuarterly
CornNegativeQuarterly
MollusksNegativeQuarterly
Digestive Survivability
Digestive SurvivabilityDescriptionUnit of Measure (LOQ)Testing Frequency
Simulated Human Intestinal Microbial Ecosystem [SHIME®]≥ 90% survival2x per year (at minimum)
Disintegration<30 minutesEach batch
DescriptionUnit of Measure (LOQ)Testing Frequency
Simulated Human Intestinal Microbial Ecosystem [SHIME®]≥ 90% survival2x per year (at minimum)
Disintegration<30 minutesEach batch
Thermostability
ThermostabilityDescriptionUnit of Measure (LOQ)Testing Frequency
Up to 10 days at 100ºF≥ Label claim for AFU2x per year (at minimum)
Up to 2 days at 120ºF≥ Label claim for AFU2x per year (at minimum)
DescriptionUnit of Measure (LOQ)Testing Frequency
Up to 10 days at 100ºF≥ Label claim for AFU2x per year (at minimum)
Up to 2 days at 120ºF≥ Label claim for AFU2x per year (at minimum)
Whole Genome
Sequencing
Whole Genome SequencingDescriptionUnit of Measure (LOQ)Testing Frequency
A series of involved genetic tests down to the strain level≥ Label claim for AFU (strain specific)Under development
DescriptionUnit of Measure (LOQ)Testing Frequency
A series of involved genetic tests down to the strain level≥ Label claim for AFU (strain specific)Under development
Water Activity
Water ActivityDescriptionUnit of Measure (LOQ)Testing Frequency
(aW) - Dew Point Method< 0.20 aW (inner and outer cap)Each batch
DescriptionUnit of Measure (LOQ)Testing Frequency
(aW) - Dew Point Method< 0.20 aW (inner and outer cap)Each batch

Probiotic Potency (AFU Quantification)

DS-01™ measures viable cell count in AFU, or Active Fluorescent Units. AFU is measured with flow cytometry, a process where probiotic cells are tagged with fluorescent ‘markers’ and counted by a laser as they pass through a tube. Through AFU, we are able to calculate precise measurement of all viable cells, including ones that are efficacious, but not necessarily culturable (and therefore would not be counted in a traditional plated CFU measurement).

CFU stands for Colony Forming Units, and is reflected in plating, a classical microbiology technique that has been used since the 1800s. This technique shows the number of ‘colonies’ that are formed on a plate through a series of dilutions. CFU can vary up to 50% between batch lots, requires different plating ingredients for each species (and sometimes strain), and is best used for single strain, rather than multi-strain probiotics, or synbiotics.

Globally, there is a lot of discussion about current and future techniques for testing beyond CFU, including flow cytometry and qPCR (Quantitative Polymerase Chain Reaction), as probiotic strains can vary widely in potency based on biofermentation and production methods (from between 50 Billion AFU / gram to 800 Billion AFU / gram). As a company committed to innovation, we are always evaluating the most effective and precise technologies, including new stabilization techniques, delivery formats, and testing methods.

Today, the use of flow cytometry and its unit of measure (AFU) not only allows us to determine viable cell counts, but also allows us to precisely measure each organism in a complex community or multi-species, multi-strain formulation. Traditional plating techniques (CFU) are extremely variable when enumerating multi-species, multi-strain formulations and are further limited by parameters of time, specifically the inability to detect viable but nonculturable (VBNC) micro-organisms and nonviable cells. More specifically, AFU detection is equal to or better than CFU for the following reasons: accuracy, precision (repeatability), intermediate precision (ruggedness), specificity, limit of quantification, linearity, range, and robustness.

Heavy Metals Testing

MetalSafe Harbor Levels
(mcg/day)
DS-01™
(mcg/day)
% Prop 65 limits
in DS-01™
Arsenic100.0820.82%
Cadmium4.10.0290.71%
Lead0.50.0306.07%
Mercury0.30.0123.93%
MetalSafe Harbor Levels
(mcg/day)
Daily Synbiotic
(mcg/day)
% Prop 65 limits
in Daily Synbiotic
Arsenic100.0820.82%
Cadmium4.10.0290.71%
Lead0.50.0306.07%
Mercury0.30.0123.93%

Most supplements, fruits, vegetables, milk-derived proteins, and natural products carry some level of heavy metals, which can be very difficult to completely eliminate from the diet due to their uptake by plants from the surrounding air, water, and soil. Food and natural products are regulated in California by CA Prop 65, or 'The Safe Drinking Water and Toxic Enforcement Act of 1986', which establishes 'safe harbor levels' for a list of chemicals known to the state to potentially cause cancer or reproductive toxicity. Seed abides by these stringent regulations and tests all products for the four main categories of Heavy Metals: Arsenic, Cadmium, Lead, and Mercury. As demonstrated in the table below, DS-01™ falls well below the established limits.

Pesticide Testing

Each batch of our final product is tested at third party accredited laboratories for over 400 pesticide residues using gas chromatography with tandem mass spectrometry. Testing certifies that each of the evaluated chemicals is absent or below the limit of quantitation of 0.010 mg/kg. 

We specifically test each batch of the DS-01™ for the ubiquitous pesticide Glyphosate as well as its breakdown product, AminoMethylPhosphonic Acid (AMPA), using liquid chromatography with tandem mass spectrometry. Results show that glyphosate and AMPA are undetectable in the DS-01™, at a limit of quantitation of 10 parts per billion. 

The full list of pesticides tested may be viewed here.

Allergen Testing

Each batch of the DS-01™ is tested and verified free of all 14 classes of allergens according to EFSA.

AllergenDS-01™
Daily Dose
Reference Dose
(in milligrams of protein)
Cashewsundetectable; below limit of quantitation0.5 milligrams
Celeryundetectable; below limit of quantitation0.07 milligrams
Glutenundetectable; below limit of quantitation0.7 milligrams (wheat protein)
Crustaceansundetectable; below limit of quantitation26.2 milligrams (shrimp protein)
Eggsundetectable; below limit of quantitation0.2 milligrams
Fishundetectable; below limit of quantitation2.6 milligrams
Hazelnutundetectable; below limit of quantitation0.1 milligrams
Lupin32-34 micrograms (0.4 - 0.43% of the Reference Dose)2.9 milligrams (or 4,000 micrograms)
Milkundetectable; below limit of quantitation0.2 milligrams
Molluscsundetectable; below limit of quantitationNot calculated*
Mustardundetectable; below limit of quantitation0.07 milligrams
Nuts
(tree nuts¹, excludes peanuts)
undetectable; below limit of quantitationHazelnut: 0.1 milligrams
Cashew: 0.05 milligrams
Other tree nuts: Not calculated*
Peanutsundetectable; below limit of quantitation0.2 milligrams
Sesame seedsundetectable; below limit of quantitation0.1 milligrams
Soyaundetectable; below limit of quantitation0.5 milligrams
Sulphiteundetectable; below limit of quantitationNot calculated*
AllergenDS-01™ Daily DoseReference Dose
(in milligrams of protein)
Cashewsundetectable; below limit of quantitation0.5 milligrams
Celeryundetectable; below limit of quantitation0.07 milligrams
Glutenundetectable; below limit of quantitation0.7 milligrams (wheat protein)
Crustaceansundetectable; below limit of quantitation26.2 milligrams (shrimp protein)
Eggsundetectable; below limit of quantitation0.2 milligrams
Fishundetectable; below limit of quantitation2.6 milligrams
Hazelnutundetectable; below limit of quantitation0.1 milligrams
Lupin32-34 micrograms (0.4 - 0.43% of the Reference Dose)2.9 milligrams (or 4,000 micrograms)
Milkundetectable; below limit of quantitation0.2 milligrams
Molluscsundetectable; below limit of quantitationNot calculated*
Mustardundetectable; below limit of quantitation0.07 milligrams
Nuts
(tree nuts¹, excludes peanuts)
undetectable; below limit of quantitationHazelnut: 0.1 milligrams
Cashew: 0.05 milligrams
Other tree nuts: Not calculated*
Peanutsundetectable; below limit of quantitation0.2 milligrams
Sesame seedsundetectable; below limit of quantitation0.1 milligrams
Soyaundetectable; below limit of quantitation0.5 milligrams
Sulphiteundetectable; below limit of quantitationNot calculated*

¹ Almond, Hazelnut, Walnut, Cashew, Pecan Nut, Brazil Nut, Pistachio Nut, Macadamia Nut (also known as Queensland Nut)

* Inadequate number of clinical studies using low dose oral challenges with this allergen.

Digestive Survivability Testing (SHIME®)

To evaluate the survival of our probiotics, we test with a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)—the closest system developed to model human digestion and the gut. It recreates the physiological conditions and biological processes (food uptake, peristalsis, digestive enzymes, pancreatic and bile acids, and time spent in each step) representative of the human gastrointestinal tract.

image-the-shime-process
Fig. 2 — The SHIME® Process

At the three hour mark of incubation, the ViaCap® delivered a maximal release of probiotics maintaining the full value of the starting dose (10.57 log vs 10.60 log, or about 100%), indicating viability through the end of the small intestine for delivery into the colon. The ViaCap® was engineered for a precision release of the contents of the inner, probiotic capsule, through the small intestine, resulting in full delivery of label potency prior to entering the colon chamber.

Thermostability Testing

Heat typically injures or kills living probiotics, but the selection of probiotic strains and the delivery system that carries them (think: capsules, powders, liquid fill) each respond differently to varying levels of heat exposure. We've tested our strains and ViaCap® capsule-in-capsule delivery system mimicking the packaging and worst-case scenario heat conditions that DS-01™ could potentially encounter on its way to our customers.

Even after 10 days of constant, 24 hour, 100º F exposure, which is very unlikely even in the heat of summer, our probiotic bacteria counts and viability exceeded the living cell counts (AFU) stated on our label.

Only with constant exposure to blazing temperatures of 120ºF—continuously over 48 hours—did the total biopotency of the DS-01™ dip below label claim numbers and requirements.

Interactions

DS-01™ is safe to take with other supplements and there are no known contraindications with medications. We would recommend that you also consult with your personal physician in regards to your prescription medications so that they may advise with the complete knowledge of your health history.

Can I take too many probiotics?

Unlike with some vitamins and minerals, probiotics do not have recommended upper limits and have not been shown to reach levels of toxicity. In fact, probiotics have been clinically studied for certain indications in CFU dosages that reach the trillions. It is important to note, more is not necessarily better—the best dose per strain of probiotics is the dose that has been shown in human clinical trials to have the intended health benefit.

Can I take DS-01™ with other probiotics?

DS-01™ is safe to take with other supplements, including another probiotic. There may be some functional redundancy if combining our probiotic with other microbial strains in the Lactobacillus and Bifidobacteria genera, but it will not hurt to do so.

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