Male Daily Synbiotic

Your Daily Synbiotic (probiotics + prebiotics)—good bacteria and nutrients good bacteria use to help you thrive. Developed for systemic benefits and formulated with strains you can’t find in yoghurt or fermented foods and beverages.

No refrigeration necessary.
$49.99 / month

Free shipping - complimentary travel vial

Retail $59.99
Skip or cancel any time
30 day guarantee
Bacteria with Benefits
(Your biome will thank you.)

$49.99 / month

30 day supply

Free shipping - complimentary travel vial

Retail $59.99
Skip or cancel any time
30 day guarantee

Bacteria are essential.

You are home to a community of 38,000,000,000,000 microorganisms (mostly bacteria). This is your microbiome. Among their many roles, bacteria aid in digestion and metabolism, and produce key vitamins, metabolites, and neurotransmitters. But, modern living and our daily choices disrupt our inner ecosystem and compromise our health beyond simple digestive issues.

The microbiome offers a more proactive approach to health. Alongside diet, exercise, and lifestyle, probiotics and prebiotics are complementary tools to care for our whole selves, not just our human part.

Why Seed?

‘Gut mania’ has put consumers around the world ahead of the science. Despite the ever-increasing number of probiotic supplements, foods, and beverages, consumers are confused about what they are, how they work, and why they should take them. The science of probiotics demands precision, accountability, and efficacy. We combine human clinical research, proprietary technology, and innovations in biofermentation, formulation, stabilization, and testing, to set a new standard for bacteria.

20 clinically-studied, naturally-occurring, human-derived strains. Not animal or soil. Validated in 23+ clinical studies. Not found in yoghurt, most supplements, or fermented foods and beverages.

A new class of patented, plant-based prebiotic compounds sourced from Indian pomegranate and Scandinavian chaga mushrooms and pine bark. Think: what bacteria use to do their best work.

Patented algae delivery and stability system ensures bacteria stay alive and viable through all stages of digestion, and make it to the colon. Bonus: no synthetic or chemical coating, and no refrigeration required up to 26 C / 79 F.

How bacteria are cultured impacts their viability. Our biofermentation is optimized for pH, temperature, and 28 other critical growth factors. Our mediums contain no meat or dairy.

Biofermentation time, prebiotic seasonality, transportation sensitivities, testing protocols, and a 135-day production cycle, mean we can only produce in specific amounts a few times a year.

We adhere to the highest global regulatory standards—EFSA (Europe) and FOSHU (Japan)—and rigorously test beyond what's required.

Based on 35 years of research and work in the microbial sciences, Seed’s Daily Synbiotic marks the evolution of probiotics and represents the true potential of beneficial microbes for human health.
Dr. Gregor Reid, PhD, MBA, Chief Scientist
Former President of ISAPP
Chair, United Nations - World Health Organization
Expert Panel that authored definition of 'probiotics'

What are the benefits?

Our bodies are complex and interconnected; positive change in one area can often trigger systemic improvements in overall health. This is the hallmark of an ecosystem and the foundation of our approach. It’s also why our benefits are extensive, yet precise.

Each beneficial claim we make is backed by rigorous science—including peer-reviewed, double-blind, published studies and our own human clinical work. Our Chief Scientist, Dr. Gregor Reid, and our Scientific Advisory Board oversee and evaluate this process. For strain specific studies, visit our Reference Library.
Here's what the science says:
  • Improves digestive health (helps maintain regularity, eases bloating, and can alleviate occasional constipation)*
  • Supports gut health*
  • Helps maintain healthy gut function*
  • Helps improve tight junction function in-vitro*
  • Supports gut barrier integrity from endotoxin-induced permeability in-vitro*
  • Promotes heart health*
  • Supports key markers related to cardiovascular health.*
  • Supports gastrointestinal immune function*
  • Helps against oxidative stress*
  • Increases metabolism of short-chain fatty acids*
  • Supports/helps maintain healthy mitochondria function*
  • Supports cellular health*
  • Supports production of urolithin-A in the body*

What's inside?

Male Daily Synbiotic Formulation:

Bifidobacterium breve SD-BR3-IT
Lactobacillus rhamnosus SD-LR6-IT
Lactobacillus plantarum SD-LP1-IT
Lactobacillus acidophilus SD-LA2-IT
Bifidobacterium longum SD-BB536-JP
Lactobacillus reuteri SD-LRE2-IT
Bifidobacterium lactis SD-BS5-IT
Streptococcus thermophilus SD-FP4-IT
Bifidobacterium infantis SD-M63-JP
Bifidobacterium lactis SD150-BE
Lactobacillus rhamnosus SD-GG-BE
Lactobacillus reuteri RD830-FR

Bifidobacterium longum HRVD90b-US
Lactobacillus rhamnosus HRVD113-US
Lactobacillus casei HRVD300-US
Bifidibacterium lactis HRVD524-US
Bifidobacterium breve HRVD521-US

Lactobacillus plantarum SD-LDL400-UK
Bifidiobacterium lactis SD-MB2409-IT
Bifidobacterium longum SD-BL4-IT

Indian Pomegranate [whole fruit and skin] (Punica granatum)
Organic Scandinavian Chaga Mushroom [mycelium] (Inonotus obliquus)
Organic Scandinavian Pine [bark] (Pinus sylvestris)

Free From:

Dairy • Gluten • Corn • Soy • GMOs • Binders • Fillers • Flowing Agents • Excipients • Preservatives • All 12 classes of allergens defined by (EFSA) – European Food and Safety Authority

Adheres To:

Vegan • Vegetarian • Kosher • Halal • Ketogenic

It takes a world.

Formulated in California • Probiotics banked in UK, France, Italy, Spain, Belgium, US, and Japan • Prebiotics sourced in India and Scandinavia • Biofermented in France and Italy • Sequenced and tested in Denmark and US • Microencapsulated in Belgium • Bottled in California

Here’s how Seed stacks up:

 Seed Most Probiotics  Yogurt Kombucha
Human-derived strains Few
Strain-specific human clinical studies Rare

Patented, non-fermentable prebiotics

Algae-based microdelivery technology

Shelf stable at room temperature


Controlled for Water Activity (aw)


Whole genome sequencing

Tested for CFU and AFU/TFU

Proven survivability through digestion


Free of excipients, binders, and agents

Few N/A N/A

Highest global regulatory adherence

See more details

We're serious about testing.

We're serious about testing.

When it comes to bacteria, precision is critical. We test beyond what’s required to ensure you get what you need, in clinically-verified dosages, with demonstrated efficacy and safety.


Seed is the first probiotic to conduct whole-genome testing—the application of shotgun sequencing to microbial DNA to understand biodiversity and function and measure relative abundance.

Translation: We know which strains are present, and in what ratios.


Strain Characterization + Metagenomic/Full Genome Sequencing


Metagenomic/Full Genome Sequencing


CFU stands for colony-forming units, and is a common form of measurement for quantifying how many bacteria in probiotics are capable of dividing and forming colonies.

Unfortunately, CFU is often used as a marketing tool. Many probiotics today proclaim outrageously enormous CFU counts, but are unable to survive the trip from manufacture to store shelf, much less the journey from your mouth, through your acidic digestive process, to your gut.

Our patented algae-delivery technology demonstrates proven survivability through digestion and maintains 18-month shelf stability with no refrigeration necessary up to 26 C / 79 F.

For further precision, we measure AFU (active fluorescent units) and TFU (total fluorescent units) in addition to CFU. AFU and TFU are measured with flow cytometry, a process where probiotic cells are tagged with fluorescent ‘markers’ and counted by a laser as they pass through a tube. Through AFU, we are able to calculate all viable cells, including ones that are efficacious but not necessarily culturable (and therefore would not be counted in a traditional plated CFU measurement).

With over 50 quality assurance and quality control (QA/QC) checkpoints, we monitor purity under both US and European protocols (including cGMP + HAACP) throughout the production cycle.

Our process includes extensive testing to ensure we understand how our probiotic strains interact with one another, human cells, and even yeast, fungi, and antimicrobials.

Bacteria are sensitive. They must be cultured with care to ensure viability—for example, even trace amounts of moisture or light can be devastating. We optimize biofermentation conditions for pH, water activity, temperature, and 28 other factors.

"Peer Reviews"

"Peer Reviews"

“I can say I’ve never used a probiotic that I actually noticed the effects of so soon after starting it. We’ve been preaching your gospel to friends.”

Daniel, Los Angeles

I love your product, it has immensely helped my stomach issues.”

Michael, Los Angeles

“They aim to rely on real science to create their product, a probiotic designed to support the vibrant ecosystem of bacteria[…]Seed’s Chief Scientist is a microbiologist who chaired the World Health Organization panel that first defined the term ‘probiotics.'”

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“I have had either constipation or diarrhea for years, but mostly constipation. Since taking The Daily Synbiotic, I’ve had easy bowel movements at the same time each day, twice a day.”

Alex, Los Angeles

“I am seeing benefits from Seed, I feel less hungry all the time and my gut is calmer. Keep up the great work!”


“I’m already loving and noticing great results from taking Seed.”

Frank, Oregon

“We’re at a fascinating point in science where we are starting to understand the microbiome and Seed is on the leading edge of that knowledge. Seed is the first probiotic that really works and that means it can significantly help your digestion, which in turn can cause better health and moods.”

Jamie, Brooklyn

“Discovering Seed has inspired me to be more aware of what I’m putting in my body and how new foods and supplements make me feel.”

Ray, Brooklyn

So excited to see what Seed has in store and look forward to the journey!

Floyd, Los Angeles

Questions we love to answer.

Seed’s Daily Synbiotic combines clinically-verified, naturally-occurring, human-derived probiotics strains (not found in yoghurt, most supplements, or fermented foods and beverages) with a new class of patented plant-based, non-fermenting prebiotics sourced from Indian pomegranate and Scandinavian chaga mushroom and pine bark. It’s available in both female (24 strains) and male (20 strains) formulations.

It’s the first to take a Microbe-Systems Approach with strain-specific benefits beyond digestive health, including heart health, skin health, immune function, reproductive health, gut barrier integrity, and oxidative stress. The female formulation is also the first to increase folate production from within the body.

The Daily Synbiotic is meant for humans ages 18+.

The Daily Synbiotic provides benefits around gastrointestinal function, gut barrier integrity, cardiovascular health, metabolism and energy production, inflammation and immune function, and oxidative stress.


The Daily Synbiotic is free from: Dairy • Gluten • Soy • GMOs • Binders • Fillers • Flowing Agents • Excipients • Preservatives • All 12 classes of allergens defined by (EFSA) – European Food and Safety Authority

It adheres to the following diets: Vegan • Vegetarian • Kosher • Halal • Ketogenic

Adults—take 3 capsules daily, all at once. Preferably on an empty stomach, at least an hour prior to a meal containing fiber, or at night before bed. You may also open capsules and mix with water.

Yes, the Daily Synbiotic is safe to take with other supplements.

Everyone’s body is different, and the benefits you ‘feel’ (reduced bloating, more regular bowel movements, higher energy) are often just the most visceral ones.

Many people feel results in as a little as 24-48 hours due to localized benefits like improved digestion. Other longer term benefits like cardiovascular health and metabolic function may take longer, or you may not notice anything at all. That’s completely normal. As long as you continue your daily intake, those beneficial microbes are doing their work inside to program, sustain, and enhance your health.

The short answer is no. No refrigeration necessary up to 26 C / 79 F.

It’s a question we receive often, especially since so many probiotics are sold in refrigerated section at grocery and natural retailers. Oftentimes, this refrigeration is a precaution to extend shelf life rather than a sign of ‘freshness’. In fact, if a probiotic does not survive at ambient temperature (79 degrees Fahrenheit) outside of the refrigerator, it can reflect weak stability of the product, low viable organism count, or inadequate overages in the formulation.

Our probiotic strains are stable up to 79 degrees Fahrenheit – so if your house is warmer than that for extended periods, it’s better to store the bottle in the refrigerator. At time of manufacture, we also include significant overages to counteract any short term heat based stress (both formulations contain 180% of viable probiotic cells at time of manufacture), which is an industry-leading practice.

If you do store the probiotic in the refrigerator after opening, please note that since the seal has been broken we recommend storing the jar inside an airlock container or Ziploc bag to minimize exposure to moisture and condensation from the refrigerated interior.

Have another question? Visit our FAQ or inquire—[email protected]

This isn’t just about your gut.

In collaboration with our scientists and partners around the world, Seed translates advances in microbiome research to develop probiotics that target the whole-body biome.

Come with us.

Wonderful. We'll be in touch.
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