Label 101

What is this label for?

This is the Supplement Facts Label. Currently, in the United States, probiotics and prebiotics are classified as supplements. Unfortunately, this also means they are more loosely regulated than foods or drugs. While we adhere to all FDA requirements, we actually look to meet and surpass more stringent global standards, such as EFSA in Europe and FOSHU in Japan.

Nevertheless, this Supplement Facts label tells you a lot of useful information about the contents of our Daily Synbiotic. We know these things are sometimes confusing, so let’s go through it together.

What’s the difference between a Supplement Facts label and a Nutrition Facts label?

The FDA is in charge of regulating both food and dietary supplements, and each category gets its own label and different labeling requirements. Since there’s no established daily value for many supplements, the Supplements Facts label must indicate the ingredients and quantities for each.

What is the algae delivery technology?

Our patented algae microsphere delivery system ensures your most sensitive strains make it through digestion and into your colon.

Why do I have to take 2 capsules every day?

Our Daily Synbiotic consists of clinically-verified dosages of both probiotics (24 strains) and prebiotics. This means that the dosage amount of each strain and prebiotic compound is confirmed via clinically-validated data. And when you add it all together, your daily dose fills 2 capsules.

Myth bust: probiotics don’t need to colonize (take up permanent residence) in your gut to work. Our probiotic strains are transient microbes, which journey through your colon (where the majority of your microbiome resides), to activate systemic benefits through programmed interactions with your existing bacteria and your body (their host). That’s why continuous, daily intake is important. It’s the clinically-verified dosage to optimize for the most impact.

What does AFU mean?

In addition to CFU, we test for AFU (Active Fluorescent Units)—the most advanced and precise enumeration method for probiotics today. These are measured through flow cytometry, a process where probiotic cells are tagged with fluorescent ‘markers’ and counted by a laser as they pass through a tube. Through AFU, we are able to calculate a more precise measurement of all viable cells, including ones that are efficacious but not necessarily culturable (and therefore would not be counted in a traditional plated CFU measurement—what you’re probably used to seeing on probiotics labels).

If you’re not familiar, CFU stands for Colony Forming Units, and is reflected in plating, a classic microbiology technique that has been used since the 1800s. This technique shows the number of ‘colonies’ that are formed on a plate through a series of dilutions. While it remains the industry standard, CFU is not an exact science. It can vary widely between batch lots, and it is ineffective for multi-strain probiotics, as different strains of bacteria require different growth media.

What do these letters and numbers indicate?

The letters and numbers designate the strain. For example, in Bifidobacterium breve SD-BR3-IT, ‘Bifidobacterium’ is genus, ‘breve’ is the species, and ‘SD-BR3-IT’ is the strain specification.

Why is strain specificity important? Well, precision is critical, especially with bacteria. Within each species, there are actually multitudes of strains. Just like a french bulldog is quite different from a golden retriever (even though they both belong to the genus and species Canis lupus familiaris), each strain of a bacterial species has its own characteristics and cannot be lumped together synonymously. As an example, Lactobacillus plantarum 299v has been shown to effectively reduce IBS symptoms in a number of trials, whereas administration of Lactobacillus plantarum MF1298 was actually found to worsen them.

In selecting a probiotic, look for full strain names on the label, and then ask for the clinical studies and research that support each strain and the benefits it claims to confer.

What does the Seed Digestive Health / GI Immunity / Gut Barrier Integrity Probiotic Blend do?

Gastrointestinal Health

• Supports digestive health (to maintain regularity, ease bloating, and can alleviate occasional constipation)*
• Helps improve stool hydration and ease of evacuation*
• May alleviate occasional gastrointestinal discomfort associated with increased intestinal transit time*

Gut Barrier Integrity

• Helps maintain healthy gut barrier function and integrity*
• Improves tight junction function in vitro*
• Supports gut barrier integrity from ethanol- and endotoxin-induced (lipopolysaccharide) permeability in vitro*

Gut Immune Function

• Supports healthy gut immune function and ‘cross-talk’ between immune and intestinal cells*
• Supports healthy immunological responses in the gastrointestinal tract*
• Increases production of short-chain fatty acids*
• Attenuates lipopolysaccharide induced response in vitro*

What does the Seed Dermatological Health Probiotic Blend do?

• Promotes healthy skin*
• Reinforces healthy gut-skin axis*

What does the Seed Cardiovascular Health Probiotic Blend do?

• Promotes heart health*
• Helps maintain blood cholesterol levels already in the normal range*
• Supports healthy intestinal recycling of cholesterol and bile*

What does the Seed Micronutrient Synthesis Probiotic Blend do?

• Supports folate (vitamin B9) production via intestinal synthesis of bioactive forms of folate*
• Supports intestinal synthesis of B vitamins involved in methyl group metabolism*

Where are Seed’s prebiotics sourced from?

While most prebiotics today fall into the category of dietary fibers such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), or inulin, our Microbiota-Accessible Prebiotic [MAP] Blend introduces an entirely new class of patented, plant-based prebiotic compounds that are biotransformed by gut bacteria into beneficial metabolites for the body.

The MAP Blend includes polyphenols from Indian pomegranate, polysaccharides from Scandinavian chaga mushroom, and oligomeric proanthocyanidins from Scandinavian pine. These ingredients are non-fermentative, meaning, unlike FOS, GOS, and inulin, they are not fermented by gut bacteria (fermentative activity can sometimes cause discomfort).

What are these 'other ingredients'?

Our 100% vegan capsule is made of hypromellose (instead of gelatin), gellan gum (which is actually produced through bacterial fermentation), and organic rice fiber and extract. The capsules are acid-resistant and delayed-release, to further protect our probiotics from the digestive process so they survive the trip to your colon.

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