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DS-01® Daily Synbiotic
DS-01® Daily Synbiotic
PDS-08® Pediatric Daily Synbiotic
VS-01™ Vaginal Synbiotic
Order Inquiries + Subscription
Shipping + Billing
International
Help
DS-01® Daily Synbiotic
DS-01® Daily Synbiotic
PDS-08® Pediatric Daily Synbiotic
VS-01™ Vaginal Synbiotic
Order Inquiries + Subscription
Shipping + Billing
International

844.646.3586

care@seed.com

DS-01® Daily Synbiotic

Seed’s DS-01® combines 24 clinically and scientifically studied probiotic strains (not found in yogurt, most supplements, or fermented foods and beverages) with a non-fermenting prebiotic compound concentrated from Indian pomegranate.

It’s among the first to take a Microbe-Systems Approach with strain-specific benefits beyond digestive health, including skin health, heart health, gut immune function, gut barrier integrity, and micronutrient synthesis. It’s also among the first formulations to include a strain that synthesizes folate and increases production within the body.

DS-01® is meant for adults ages 18+.

DS-01® contains probiotic strains that have been clinically and scientifically studied to provide benefits around gastrointestinal function, skin health, heart health, gut immune function, gut barrier integrity, and micronutrient synthesis. You may access the strain-specific clinical studies associated with each benefit in our Reference Library.

Next-generation probiotics

A proprietary formulation comprising of 24 strains characterized at academic institutions and research partners in Italy, Spain, Belgium, US, and Japan. 23 of our strains are human-derived and one strain was isolated from fruit (screened against 400+ strains of the same species) specifically because it has clinically demonstrated the ability to help promote healthy cholesterol levels. Our benefits have been validated in 16 strain-specific, published human studies as well as 13 in vitro/ex vivo mechanistic studies.

Nested Capsule Technology + Patented algae delivery system

Bacteria are fragile—they are sensitive to light, temperature, and moisture. In many cases, they hardly survive the trip from manufacturer to store shelf, much less your digestive process (think stomach acids and bile). We took care of this. Our exclusive nested capsule technology ensures bacteria stay alive and viable through digestion and make it to your colon, where their work begins. We use a patented algae delivery system to provide additional protection for our most sensitive strains. This also means there’s no synthetic or chemical coating, and that DS-01® requires no refrigeration.

DS-01® is tested for: Dairy, Gluten, Soy, GMOs, Nuts, Shellfish, Sesame, Glyphosate/AMPA, and 14 classes of allergens defined by European Food and Safety Authority (EFSA)

It adheres to the following diets: Vegan • Vegetarian • Ketogenic • Gluten-Free • Intermittent Fasting.

DS-01® does not contain genetically modified organisms, and as such, is classified as non-GMO.

However, as a company grounded in science, we also want to ensure that labeling our product as non-GMO doesn’t contribute to blanket fears and misunderstandings of GMOs in general. Just as we aim to steward the term probiotics, there are scientists and researchers working to steward the field of synthetic biology and bioengineering towards applications that can save many lives (i.e. insulin—without genetic engineering we would not be able to meet demand) and ensure humanity’s survival on this planet, while protecting the planet itself (i.e. genetically engineered bacteria that can create biomaterials to replace plastic or produce biofuels affordably, efficiently, and sustainably).

Like bacteria, GMOs have faced a long and complex history. Like any industry or category, there are those who don’t have the consumer’s best interests in mind, but also those who will relentlessly push for us to use biotechnology responsibly, for the benefit of the planet and its people. Whatever your stance on GMOs, the only way forward is an open mind and open dialogue.

As with any dietary supplement or new health protocol contemplated during pregnancy or lactation, we recommend speaking with your physician or obstetrician before you start consuming DS-01® Daily Synbiotic.

Probiotics, in general, do not appear to pose any safety concerns for pregnant and lactating individuals. The current literature does not indicate an increase in adverse pregnancy outcomes when probiotics are used by healthy individuals.

We don’t recommend this, as bacteria are sensitive to light. Our jar is designed to protect your DS-01®, so your capsules should be stored in it. Every first purchase comes with a complimentary travel vial, which holds 14 capsules (1 week’s worth), which is also safe for transporting your DS-01® on the go.

With any new diet, product, or change, your body may experience a temporary acclimation period. In the first few days of taking your DS-01®, you may feel some gastrointestinal discomfort, abdominal tightness, mild nausea, or changes in your stool. This is very normal.

An immediate physiological reaction is a sign that our probiotics are viable and attuning to your system as they move through your gastrointestinal tract. Any discomfort generally subsides within the first one to two weeks.

As you begin Seeding, we suggest this acclimation protocol:

Day 1-3

Take 1 capsule daily.

Day 4

When you’re ready, increase to the full dose of 2 capsules at once, daily.

We’re here for any questions—care@seed.com

Adults—take 2 capsules daily, all at once. Preferably on an empty stomach to limit exposure to digestive enzymes and bile salts. However, you know your body best—if it’s more comfortable for you to take with food, please feel free to do so.

2 capsules, daily.

Everyone’s body is different, and the benefits you may "feel" (ease of bloating, more regular bowel movements) are often just the most visceral ones.

It is normal to feel effects in the digestive tract in as little as 24-48 hours. Other longer term benefits like cardiovascular health and gut immune function may take longer, or you may not notice anything at all. That’s completely normal. As long as you continue your daily intake, those beneficial microbes are doing their work inside to program, sustain, and enhance your health.

DS-01® is safe to take with other supplements.

There are no known contraindications with DS-01® and any over the counter or prescription medications, though we encourage you to double check with your physician before adding our product to your regimen.

We recommend taking DS-01® on an empty stomach to limit exposure to digestive enzymes and bile salts. However, you know your body best—if it’s more comfortable for you to take with food, please feel free.

It’s safe to take more than the recommended dosage, though there is not necessarily any added benefit.

It’s safe to take if expired, however, we only guarantee potency and efficacy up until the expiration date. If your product is expired when you receive your order, please let us know and we will replace it free of charge.

There’s no harm if you miss a day, or even if you miss a few. But for optimal results, daily intake is encouraged.

This is because our probiotics are transient microbes, which journey through your colon (where the majority of your microbiome resides) to activate systemic benefits through programmed interactions with your existing bacteria and your body. That’s why continuous, daily intake is important using clinically and scientifically studied strains and dosages.

The short answer is no. No refrigeration necessary.

It’s a question we receive often, since many probiotics are sold in the refrigerated section at grocery stores and retailers. However, contrary to perishable food products, refrigeration doesn’t mean "freshness" or superiority. In fact, if a probiotic does not survive at ambient temperature outside of the refrigerator, it can reflect weak stability of the product, low viable organism count, or inadequate overages in formulation.

If your home is consistently warmer than 79° F for extended periods, consider refrigerating in an oxygen tight container to avoid exposure to moisture.

PDS-08® Pediatric Daily Synbiotic

PDS-08® Pediatric Daily Synbiotic is a clinically studied 2-in-1 powdered probiotic + prebiotic, formulated for children and adolescents ages 3-17 with 9 probiotic strains and a fiber-based prebiotic.

PDS-08® Pediatric Daily Synbiotic is meant for children and adolescents ages 3–17, as this is the age group in which our product and probiotic strains have been evaluated for efficacy and tolerability.

PDS-08® was formulated in a powdered format for several reasons—including ease of use in a pediatric population (children cannot easily swallow capsules) and the ability to incorporate a clinically meaningful dose of prebiotic fiber. Our powdered format also allows for the use of heat-sensitive probiotic strains (which would otherwise be damaged in the manufacturing of formats like gummy-based probiotics).

Probiotics and prebiotics, alongside foundational lifestyle factors, can provide support for a healthy microbial ecosystem.

Over the past decade, research has illuminated the significant role of the microbiome in a developing child and how factors like diet, exercise, environment, use of antibiotics, sleep, and hygiene can impact critical windows of development and inform their systemic health through adulthood. Alongside these factors, probiotics for adults, adolescents, and children have tremendous potential to modulate and support one’s health. Still, appropriate skepticism and confusion remain due to the plethora of unvalidated benefits marketed today. 

The best solution for you and your child depends on what benefits you’re looking for. While it’s true that today, most parents and caregivers are looking for a probiotic to support (or optimize) gastrointestinal function and digestive health, it’s important to first identify that probiotics are a science and that specific strains are studied for specific outcomes, even within those areas of impact. For example, certain strains have been studied in children to impact antibiotic-associated diarrhea, whereas others have been studied to support bowel movement frequency and ease of pooping. With approximately 11% of young children experiencing antibiotic-associated diarrhea, up to 29% of the pediatric population worldwide classified as clinically constipated, and 50% of children with constipation still having problems after 5 years of treatment, along with countless other children simply experiencing anxiety or strain related to pooping, there are millions of children on Earth who can benefit from the digestive and GI impact of clinically validated probiotics. 

But as the field of probiotics has advanced alongside our understanding of the critical role that the microbiome plays in a child’s developing immune and systemic health, we can now look to probiotics for benefits beyond digestion, especially the specific strains studied to support gut-immune function, gut barrier integrity, and even respiratory and skin health. 

An additional consideration is that our modern living practices and daily choices—such as more time spent indoors (and away from natural environments), poor diet, lack of fiber, antibiotic overuse, and other environmental factors—can disrupt the microbiome, especially in critical windows of development for children. For these reasons, and alongside critical levers like diet and nutrition, specific probiotics can be an impactful way to nurture and support your child’s microbiome and systemic health beyond digestion. 

PDS-08® Pediatric Daily Synbiotic is formulated with probiotic strains that have been clinically studied to support gastrointestinal health, gut barrier integrity, gut-immune function, dermatological health, and respiratory health.

PDS-08® was studied in a double blind, randomized, placebo controlled trial, in a pediatric population to support healthy bowel function in children with a low frequency of weekly bowel movements.  

The probiotic strains in PDS-08® have been studied in various pediatric populations to support benefits for gut barrier integrity, gut-immune function, dermatological health, and respiratory health. The dosages in our product reflect the exact dose used in their respective clinical trials. 

Additionally, the composition was shown to significantly enrich Bifidobacterium in the pediatric gut microbiome (as demonstrated via metagenomic shotgun sequencing) and support the production of short-chain fatty acids (SCFAs) in vitro through the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®).

You can learn more about the science behind PDS-08® in our Reference Library here.

There is no optimal time of day for your child to consume PDS-08® Pediatric Daily Synbiotic—however, it’s often ideal at mealtime since consuming PDS-08® with food is important for maximum viability. While probiotics are a science, parenting is not—however your child prefers to take PDS-08® each day, that’s the best way.

Pick a time of day to start PDS-08® with your child—you know your child’s routine best. It may be easiest to coincide with a mealtime (and  it’s optimal to consume PDS-08® with food).

Take 1 sachet from your BacTrac™ container and pour it into a cold or room-temperature food or drink(Not hot, please.)

Mix well. Stir into food until fully mixed. If stirring into a drink, shake thoroughly in a closed bottle. Bacteria are fragile, so please no heat, blenders, or food processors, as these can impact the activity of the probiotics.

Enjoy within 30 minutes. Yes, this means all of it! As the probiotics and prebiotics are exposed to moisture, they activate and start to interact with one another. If left to sit for too long, this could lead to digestive discomfort after consumption.

Align the top of your BacTrac™ container with the day that you are starting. PDS-08® doesn't require refrigeration, so feel free to store it on your countertop.

Repeat and track so you never miss a day.

PDS-08® Pediatric Daily Synbiotic can be consumed with cold or room-temperature soft foods or liquids of choice. 

While there is no optimal food or beverage to consume PDS-08® with, we recommend trying to find a method that consistently works best for the individual taking it. Some suggestions include: water, apple sauce, yogurt, fruit puree, overnight oats, or a plant-, nut- or animal-based milk of choice.

In testing, we found that mixing PDS-08® into your child’s favorite soft foods yields optimal results. 

If you prefer to stir PDS-08® into a drink, shake thoroughly in a closed bottle. Bacteria are fragile, so please no heat, blenders, or food processors as these can impact the activity of the probiotics.

When mixed in a flavorless food or drink like water, PDS-08® Pediatric Daily Synbiotic has a mildly sweet taste due to the long-chain prebiotic fiber inulin, though no sugar or artificial sweeteners were added to the product. When mixed into soft foods or other beverages, your child may not notice any flavor at all.

1 sachet daily (or: 20 Billion AFU + 6g of prebiotic).

Each sachet contains 6.30g/0.22 oz of powder.

We suggest consuming the full daily dose of PDS-08® Pediatric Daily Synbiotic within 30 minutes to ensure maximal potency of the product. 

We know how hard it is to find evidence-based information so we can make the best choices—especially for parents. Between flavored powders and brightly colored gummies, choosing a pediatric probiotic is a challenge.

So we developed PDS-08® Pediatric Daily Synbiotic with science and simplicity in mind. PDS-08® is a clinically studied 2-in-1 powdered probiotic and prebiotic with 9 probiotic strains and a dual-phase, mixed-chain-length, fiber-based prebiotic comprised of of inulin and fructooligosaccharides (FOS). The formulation offers 5g of prebiotic fiber in each serving, which helps parents incorporate this important nutrient into their child’s diet. PDS-08® is sugar-free and easy to take on the go—no refrigeration required.

PDS-08® is the first 9-strain synbiotic studied in a double-blind, randomized, controlled trial in a pediatric cohort shown to support gastrointestinal function and a healthy frequency of weekly bowel movements. It is also the first multi-strain synbiotic to include two pioneering strains clinically validated in children to support respiratory health and a healthy response to seasonal airborne particles. 

The probiotic strains in PDS-08® have been studied in 18 clinical trials specifically conducted in various pediatric cohorts and the dosages in our product reflect the exact dose used in their respective clinical trials. This means that these strains have demonstrated a health benefit at an "effective dosage" in the same dose included in our PDS-08™ formulation.

Lastly, PDS-08® undergoes extensive testing (well beyond what’s required) throughout each step of the manufacturing process as well as on the final product. This includes testing for potency, survivability, contaminants (pesticides, mycotoxins, and heavy metals), and over 20 allergens defined by the European Food Safety Authority (EFSA).

PDS-08® Pediatric Daily Synbiotic adheres to a vegan and vegetarian diet and is rigorously monitored for 14 classes of allergens and over 20 total allergens as defined by the European Food and Safety Authority (EFSA), including dairy, gluten, soy, corn, sesame seeds, and nuts (almond, brazil, cashew, hazelnut, macadamia, peanut, pecan, pine, pistachio, and walnut)

Additionally, PDS-08® is preservative-free, Prop 65 compliant, does not contain added sugar, and is rigorously tested for glyphosate, AMPA, and over 500 other pesticides

In the double-blind, randomized, placebo-controlled trial on children ages 3–17 conducted on PDS-08® Pediatric Daily Synbiotic, there were no observed side effects or GI distress (such as pain, bloating, gas, or diarrhea) as commonly reported with many fiber-based dietary supplements, probiotics, and high-dose fermentable prebiotics. 

However, every child is physiologically unique. If you know your child is prone to digestive sensitivity, we recommend starting and acclimating with half a sachet for the first few days. Simply store the unused half in an air-tight container or bag for use the following day. When your child is ready, increase to the full dose of 1 sachet, daily.

Each individual is physiologically unique, and the benefits one may “feel” (e.g., ease of bloating or easy, frequent poops) are often just the most visceral ones.

One may feel results in as little as 24–48 hours due to localized digestive support, though other longer-term benefits for gut-immune function or respiratory health may take longer or may not be tangibly noticeable, which is normal. As long as daily intake is continued, PDS-08® is doing the work inside to program, sustain, and enhance your child’s health.

Yes—PDS-08® Pediatric Daily Synbiotic is safe to take with other dietary supplements, though we always recommend checking with your pediatrician or physician.

There are no known contraindications with PDS-08® Pediatric Daily Synbiotic and medications, therefore PDS-08® would be generally safe to take alongside any prescription or over-the-counter medications.

However, we always recommend consulting with your doctor or family physician so they may advise with the complete knowledge of your child's health history.

As there are no known contraindications with PDS-08® Pediatric Daily Synbiotic and medications, it is safe to take PDS-08® while undergoing antibiotic therapy. However, we always recommend checking with your child’s doctor or pediatrician. 

While on a course of antibiotics, we do recommend spacing out when your child takes the antibiotic from PDS-08® as far as possible—i.e., one in the morning and one in the evening.

During and after antibiotic use is a good time for probiotics, as numerous studies have evaluated  a variety of strains and combinations of strains for their ability to mitigate GI distress during antibiotic use such as antibiotic-associated diarrhea (AAD)

It's important to note, though, that probiotics are beneficial organisms that are also susceptible to being killed off by antibiotics—especially broad-spectrum antibiotics, which is why we generally recommend trying to separate intake as much as possible if they are to be taken at the same time.

It is safe to consume more than the recommended daily dose of 1 sachet, though there is not necessarily any added benefit in doing so. It is also important to note that because our prebiotic formulation is fermentative, your child could experience some mild to moderate gastrointestinal upset at a higher dose.

Simply store PDS-08® Pediatric Daily Synbiotic at room temperature in the aluminum BacTrac™ container provided in your Welcome Kit. 

There is no refrigeration necessary.

Though many probiotics are sold in the refrigerated section at grocery stores and other retailers, refrigeration doesn’t necessarily mean “freshness” or superiority. In fact, if a probiotic does not survive at ambient temperature outside of the refrigerator, it can reflect weak stability of the product, low viable organism count, or inadequate overages in formulation.

Each daily dose of PDS-08® is sealed in an individual biofilm sachet, further protecting the probiotics from environmental elements. For optimal viability, we do recommend storing in a cool, dry area. Consider refrigerating only if your home is consistently warmer than room temperature (>79° F/26° C) for extended periods.

PDS-08® Pediatric Daily Synbiotic is shelf-stable for 18 months past the manufacturing date. 

You can find the expiration date printed in black on the back of each sachet.

While PDS-08® is safe to take past expiration, we can only guarantee potency and viability up until the expiration date.

There’s no harm in missing a day, or even a few, but daily intake is important for optimal results. This is because, in general, probiotics are transient microbes, which means they travel through the digestive tract interacting with immune cells, gut cells, dietary nutrients, and existing microbes along the way (to trigger local and systemic benefits), before eventually exiting the body. This is why continuous, daily intake is important.

Probiotics, in general, are transient microbes—which means they trigger both local and systemic benefits as they travel through the digestive tract interacting with immune cells, gut cells, dietary nutrients, and existing microbes along the way before eventually exiting the body. Science has demonstrated that the benefits conferred by these transient organisms are confined to the duration of consumption or shortly thereafter, which indicates that their efficacy is dependent on continuous use. Therefore, if sustained benefits are desired, continuous, daily intake is important.

Due to the importance of consistency, we offer PDS-08® Pediatric Daily Synbiotic on a subscription basis.

Each month, you will receive a 30-day supply (30 individual sachets) of PDS-08® Pediatric Daily Synbiotic, which can be safely stored in your refillable BacTrac™ container for an additional layer of protection from light and moisture.

Your BacTrac™ container was also designed to track daily use. Simply twist the container top to align the dot (•) and day so you always remember the last date of use.

PDS-08® Pediatric Daily Synbiotic is a 2-in-1 probiotic and prebiotic formulated with 9 probiotic strains and a fiber-based prebiotic composed of inulin and FOS (fructooligosaccharides).

PDS-08® is free from sugar, artificial colorants, flavors, flow agents, binders, preservatives, and 14 classes of allergens.

You may view our complete strain list and included ingredients here.

Just as with any new diet, product, or lifestyle change, your child may experience a temporary acclimation period when first starting PDS-08® Pediatric Daily Synbiotic. This can include some gastrointestinal discomfort, abdominal tightness, mild nausea, or changes in their stool. This is normal. 

In fact, an immediate physiological reaction is a sign that our probiotics are viable and attuning to your child’s system as they move throughout the gastrointestinal tract. Any discomfort should subside within the first few weeks of consistent daily use.

If you know your child is prone to digestive sensitivity, we recommend starting with half a sachet for the first few days. When your child is ready, increase to the full dose of 1 sachet, daily.

In the United States, dietary supplements are not reviewed or approved by the FDA for safety or efficacy. However, the FDA does regulate and enforce associated claims for both dietary supplements (the finished products) and dietary ingredients (the individual constituents that comprise dietary supplements). Our PDS-08® Pediatric Daily Synbiotic adheres to all FDA established regulations for dietary supplements (current Good Manufacturing Practices, or “cGMP”) and all of its ingredients meet the definition of an allowed dietary ingredient. PDS-08® also exceeds U.S. regulations for ingredient and finished product testing and meets the highest global regulatory standards in Europe (EFSA) and Japan (FOSHU). Lastly, the FDA requires that claims made for each dietary supplement are backed by credible and systematic scientific investigations. PDS-08® enjoys 18 clinical studies on its probiotic strains and has been subjected to a placebo-controlled randomized trial to evaluate its effect on bowel movement frequency.

Our PDS-08® Pediatric Daily Synbiotic undergoes extensive testing throughout each step of the manufacturing process as well as on the final product. This includes whole-genome sequencing on our strains (translation: we know which strains are present and in which quantities), flow cytometry (flow cytometry measures Active Fluorescent Units—a more accurate way of measuring all viable cells), survivability testing to ensure the optimal conditions for our probiotics to survive transit through the GI tract, heat and humidity testing to mimic the most extreme conditions our product may encounter during shipping and storage, and over 50 quality-assurance and quality-control (QA/QC) checkpoints.

The final product is tested for 420 different pesticides (including glyphosate) and over 20 of the most common allergens as defined by the European Food Safety Authority (EFSA). Our probiotic strains have GRAS and/or QPS status, which designates them as safe for consumption by the United States and European Union, respectively.

We monitor purity under both U.S. and European protocols (including cGMP + HACCP) throughout the production cycle with lot-to-lot testing (this means we test each ingredient batch prior to encapsulation and each batch after manufacture).

VS-01™ Vaginal Synbiotic

If you miss a dose for whatever reason, simply resume your next dose as soon as possible.

Menstruation is one of the most known day-to-day disruptors of the vaginal microbiome. VS-01™ is designed to work with your body’s unique cycle by rapidly restoring your vaginal microbiome with an initial Reset, and then maintaining stability and regulated pH with monthly use.

Gently press a VS-01™ vaginal tablet out of the aluminum pack into washed hands before each use. Place the VS-01™ vaginal tablet securely into an applicator. Insert into your vagina, and push the inner tube towards you to release (just like a tampon). After releasing, remove and dispose of the applicator. Please note that each applicator is a Class I Medical Device and cannot be recycled.

VS-01™ is a two-part system designed to maximize efficacy with minimal impact on your day-to-day. You’ll begin with an intensive first month, Reset, a clinically-validated protocol consisting of six vaginal tablets. A frequent dosing schedule in your first month helps to rapidly establish an optimal vaginal microbiome and lay the foundation for ongoing VS-01™ use. 

You’ll continue with Sustain, the ongoing monthly protocol of two vaginal tablets to maintain a stable, resilient vaginal microbiome less prone to everyday pH disruptors from lifestyle and the environment.

While most available solutions target only the symptoms in ways that further disturb the vagina, VS-01™ addresses the source—the vaginal microbiome. VS-01™ begins with an intensive first month Reset to rapidly establish an optimal vaginal microbiome and continues with monthly Sustain — the simple, two-tablet monthly protocol to maintain a stable vaginal microbiome and regulate pH. 

In a double-blind, randomized, placebo-controlled clinical trial, VS-01™ restored and maintained an optimal vaginal microbiome 10x more effectively than a leading oral vaginal probiotic, and 100% of participants experienced regulated vaginal pH.

Yes, VS-01™ can be combined with other (orally administered) dietary supplements including probiotics.

There are no known contraindications or interactions with VS-01™ and dietary supplements though we encourage discussing with your physician for any questions related to your health/medical regimen.

Born from 15+ years of leading vaginal microbiome research, VS-01™ is the first vaginal synbiotic suppository formulated with three proprietary Lactobacillus crispatus strains, clinically validated to rapidly restore a healthy vaginal microbiome, sustain regulated vaginal pH and is safe for long-term use.

VS-01™ is designed for ongoing use to rapidly establish and then maintain a resilient vaginal microbiome less prone to disruptions from day-to-day life. VS-01™ is also rigorously third-party evaluated and verified safe for long-term use.

VS-01™ combines three proprietary L. crispatus strains (LUCA103™, LUCA011™, LUCA009™) isolated from the vaginal tract of healthy women with a novel  a complex of nutrients and molecules to promote the growth of the L. crispatus strains ecology and positively modify the vaginal environment. 

VS-01™ is formulated without binders, fillers, or endocrine-disrupting ingredients.

By law, dietary supplements and cosmetic products do not undergo FDA approval. However, the FDA does regulate and enforce associated claims for cosmetics, dietary supplements, and dietary ingredients. Seed adheres to all FDA established regulations for  vaginal suppositories  (current Good Manufacturing Practices, or “cGMP”), and all of its ingredients meet the definition of an allowed ingredient. Further, VS-01™ exceeds U.S. regulations for ingredient and finished product testing, and ingredients meet the highest global regulatory standards in Europe (EFSA) and Japan (FOSHU).

VS-01™ and DS-01® taken concurrently can offer a comprehensive solution to nurture both your gut and vaginal microbiomes, leading to whole health benefits across gastrointestinal health, skin health, gut-barrier function, immune health, vaginal health, and others. Since DS-01® is an oral synbiotic that targets your gut microbiome and VS-01™ is a vaginal suppository synbiotic that targets your vaginal microbiome, there are no functional redundancies when combining the two in your routine.

VS-01™ is recommended for adults ages 18-55.

Kindly note, your body’s natural lubrication is required for optimal dissolution of VS-01™. As such,  VS-01™ may not be as effective among individuals experiencing significant vaginal dryness.If you experience significant vaginal dryness, please consult your physician.

You may start Day 1 of Reset and Sustain at any time. It is important to follow the clinically validated protocol as closely as possible. Aim to start Sustain at least five to seven days after your Reset is complete.

As with any new health protocol contemplated during pregnancy, pre-conception or while nursing, we recommend consulting your physician or obstetrician before using VS-01™.

VS-01™ would generally be suitable to take alongside most prescribed or over the counter medications as there are no known contraindications between probiotics or prebiotics and medications. That said, if you are currently taking medication for an existing vaginal infection or concern, follow the standard of care prescribed and introduce VS-01™ as directed by a physician.

Ultimately, we always recommend consulting with a prescribing physician if you’re considering incorporating VS-01™ into your routine.

VS-01™ is safe to use alongside contraceptives, including an intrauterine device (IUD), vaginal ring, or oral contraceptives (birth control pill).

There are no known contraindications with VS-01™ and any over the counter or prescription medications, though we encourage double checking with your physician for any questions related to your health/medical regimen.

VS-01™ has a rigorous safety profile through clinical (in humans) and preclinical (in laboratory environments) testing. VS-01™ is extensively third-party evaluated for contaminants, heavy metals, impurities and all classes of allergens. It is formulated with gentle, non-irritating ingredients and tested for safety and vaginal biocompatibility using an FDA-recognized tissue model.

It is recommended that you do not use VS-01™ while experiencing moderate to heavy bleeding, in order to allow the VS-01™ vaginal tablet to fully dissolve in the vagina and maximize absorption. Day 1 of each protocol starts as soon as bleeding stops.

Note that it is completely fine to insert VS-01™ while spotting or experiencing light bleeding.

If you experience breakthrough bleeding, <28 day cycles, or irregular periods that may disrupt the VS-01™ protocol, do not worry. Take each tablet as close to the schedule as possible.

Start Sustain Day 1 five to seven days after your Reset is complete.

You can always modify your next VS-01™ shipment in your account dashboard or by reaching out to our care team—care@seed.com.

As with any new product or new health protocol, your body may experience a temporary acclimation period when first starting VS-01™. Effects such as discharge, mild to moderate irritation or minor cramping may occur shortly after inserting the first vaginal tablet. This should normalize as your body adjusts.

To maximize comfort, we recommend inserting VS-01™ at night and wearing a liner or pad. If you are concerned about any potentially bothersome effects or the symptoms persist or worsen consult with a physician.

Simply store VS-01™ in a cool, dry place. There is no refrigeration necessary.

An unstable vaginal microbiome, or dysbiosis, can be caused by various factors including sex, menstruation, condom use, gels and lubricants, certain prescriptions, cleansing, past pregnancy, diet, and stress. 

These factors can impact  beneficial bacteria, introduce harmful bacteria, or disrupt the natural balance of the vaginal ecosystem.

If it has been >3 months since your last VS-01™ dose, we encourage restarting with our Starter Kit, which includes the Reset protocol—six vaginal tablets to rapidly establish an optimal vaginal microbiome, and your first monthly Sustain—the two-tablet protocol to maintain stability and protect against everyday pH disruptors. Kindly reach out to our Care Team at care@seed.com for support.

We recommend inserting at night or just before bed to allow the tablet to fully dissolve overnight.

You can place an order online using your FSA or HSA card (as you would any other credit or debit card). We’ve taken all of the necessary steps on our end to ensure that you can use your FSA or HSA funds to purchase VS-01™. We also recommend consulting your provider to determine what documentation is required to have your claim approved, as many providers require a Letter of Medical Necessity (LMN) in addition to a receipt.

VS-01™ is FSA/HSA eligible. You can place an order online at Seed.com using your FSA or HSA card (as you would any other credit or debit card). We also recommend consulting your HSA/FSA fund provider or administrator as final purchase approval may vary.

Yes—you can be sexually active while using VS-01™, though we recommend abstaining from sexual activity for 12 hours after inserting a tablet, to allow the tablet enough time to dissolve completely.

VS-01™ is a two-part system designed to maximize efficacy with minimal impact on your day-to-day. 

You’ll begin with an intensive first month, Reset, a clinically-validated protocol consisting of six vaginal tablets taken on day 1, 4, 7, 14, 21, and 28. Then, continue with an ongoing Sustain protocol of two vaginal tablets (day 1 and day 14) per month to maintain a stable vaginal microbiome and regulate pH.

If you menstruate regularly, you will start VS-01™ immediately after your period when bleeding stops (spotting is okay). If you do not menstruate regularly, you can start at any time. If you experience irregular bleeding that may disrupt the protocol, simply resume your next vaginal tablet when bleeding stops. If you miss a day, simply resume as soon as possible.

Order Inquiries + Subscription

You can cancel your subscription at any time by logging into your account and clicking “Account” in the top menu. Click “Settings,” then scroll down to find the “Cancel subscription” button.

If you had any issues managing your subscription that are causing you to cancel, you can also email us at care@seed.com and we’ll be happy to assist.

If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We’ll refund you for the full cost of the product less shipping, VAT, and duties—no questions asked. Refunds apply to your first order only, not any subsequent shipments. For all subsequent shipments, you may reschedule or cancel at any time in your Account.

Kindly note that Sustainable Refill Program orders are considered final sale 30 days after delivery.

Each DS-01® subscription includes a 30-day supply (60 capsules) for $49.99/month—billed and delivered, monthly. We offer free shipping within the U.S., and a $10 flat rate for international shipments.

Each PDS-08® Pediatric Daily Synbiotic subscription includes a 30-day supply (60 capsules) for $49.99/month—billed and delivered, monthly. We offer free shipping within the U.S., and a $10 flat rate for international shipments.

Yes. We believe that probiotics and prebiotics—alongside diet, nutrition, exercise, and lifestyle—are cornerstone tools to building foundational health. In general, probiotics are transient which means continuous use is critical for consistent benefits. By signing up for a subscription, you’ll easily be able to build our synbiotics into your routine.

But we want you to feel good about what you’re taking. That’s why we offer a risk-free 30 day guarantee where you may request a refund at any time within 30 days of your first Seed order delivery.

You may also reschedule or cancel your subscription easily from your account at any time.

Your monthly subscription includes a 30-day supply of DS-01®. Your first month’s shipment is your Welcome Kit. It includes a reusable glass jar holding your first month’s supply, some Seed reading materials, and a complimentary travel vial that holds a week’s worth of your DS-01®, so you never miss a day on the go.

Your monthly subscription includes a 30-day supply of PDS-08®, with each daily dose housed in a biofilm sachet. Your first month’s shipment is your Welcome Kit. It includes a refillable aluminum BacTrac™ container holding the first month’s supply of PDS-08®, as well as some reading materials.

Each month, you will receive a 30-day supply of PDS-08®, which you can store in your refillable BacTrac™.

Yes—we’ll cover 15% of your subscription cost each month for orders shipping to the U.S. To activate, simply head to checkout then follow the prompts for a verification process through our partner (SheerID) to receive your unique code.

For any questions about your verification status, kindly reach out to customerservice@sheerid.com.

After verification, any questions about your account or subscription can be directed to care@seed.com.

Once you reset your password here, ​​you should be all set to log in successfully. For further support, please reach out to care@seed.com, and we’ll take care of it from there.

Please reach out to SeedCare at care@seed.com and we’ll gladly assist.

You’ll receive an order confirmation email after you sign up for your subscription. We’ll also send an email before we prepare each order, and you can view all of this information in your Account or by contacting us at care@seed.com.

You may update your shipping and billing information in your Account or by contacting care@seed.com.

At this time, we do not offer the option of different billing information across one account. That said, you can provide different shipping addresses for each of your subscriptions.

We do not offer bundling at this time. Your subscriptions will each ship separately.

If you would like your products to ship at a similar cadence, you can reschedule them to process at the same time. Just head to your Subscription page in your Account, then use the edit option under each subscription to select your desired billing date.

If you’re enrolled in our Sustainable Refill Program and would like to switch to a different SRP plan, please unenroll and then enroll in the plan of your choice.

Our Sustainable Refill Program allows you to opt for 3- or 6-month shipments of DS-01® Daily Synbiotic and VS-01™ Vaginal Synbiotic (it’s currently not available for PDS-08® Pediatric Daily Synbiotic). Consolidated shipments reduce the carbon emissions from shipping by 22% and offer up to $200 in savings per year.

For DS-01® Daily Synbiotic, you can opt to receive 3- or 6-month refills and save up to $90 per year.

For VS-01™ Vaginal Synbiotic, you can opt to receive 3-month refills and save up to $200 per year.

Once your first order has been processed, you’ll see the option to enroll in the Subscription page of your Account. You can un-enroll at any time.

If you’ve fallen a bit behind on your routine, don’t worry—our products undergo stability testing to ensure that the full potency is retained up until the end of shelf-life. Please refer to the expiration date on each refill you have on hand.

And in the meantime, you can also reschedule your next refill. Just head to the subscription page in your account, and you’ll see the option to edit your refill date.

Your VS-01™ Vaginal Synbiotic subscription starts with a two-month Starter Kit at $99. After this first shipment, each refill provides a one-month supply for $39.99/month. 

We offer free shipping within the U.S., and after your first VS-01™ order  we also offer the option of discounted 3-month refills through our Sustainable Refill Program.

Shipping + Billing

Visa, MasterCard, American Express, Discover, PayPal, Apple Pay, and Amazon Pay. We unfortunately cannot accept cash, checks, money orders, bitcoin, or hugs. 🙂

Shipping to the U.S.: free

Shipping internationally: $10 flat rate (USD) (+ any local taxes and duties).

International subscribers who enroll in our Sustainable Refill Program receive free shipping (local taxes/duties still apply). At this time, our Sustainable Refill Program is only available for DS-01® Daily Synbiotic and VS-01™ Vaginal Synbiotic.

If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We’ll refund you for the full cost of the product less shipping, VAT, and duties—no questions asked. Refunds apply to your first order only, not any subsequent shipments. For all subsequent shipments, you may reschedule or cancel at any time in your Account.

We do not offer bundling at this time. Your DS-01® subscription and your child’s PDS-08® subscription will ship separately. If you would like to receive them on the same shipping cadence, you may log into your Account and select the same "next shipment date" for both subscriptions.

You are billed each month when your subscription renews, using the payment method you have on file. You’ll always receive a reminder email 3 days before your order is due to bill. This charge will occur approximately every 28-30 days, unless you cancel. You may view your next shipment date in your Account.

If enrolled in our Sustainable Refill Program, you are billed every 3 or 6 months, based on your delivery cadence.

Please note that when signing up for a new subscription or reactivating a prior subscription, you will be immediately billed for a new order.

We are a certified PCI DSS compliant service provider. This means we take your security very seriously and never disclose your personal identity or information with anyone. You can read our full Privacy Policy here.

We’ve conducted extensive heat testing on our products—after 10 days of constant, 24 hour, 100º F exposure (which is highly unlikely even in the heat of summer), our probiotic bacteria counts and viability exceeded the living cell counts stated on our label.

DS-01® and PDS-08® won’t be affected in temperatures below freezing as well. In fact, freezing and below freezing temperatures are good at keeping the bacteria in an ideal state. 

Depending on the temperature of your home (or where you are traveling), kindly follow the recommended storage guidelines.

Discounts can be applied in your shopping cart or at checkout—just click “Have a promo code”? to apply.

Kindly note, our discount system only honors one discount at any given time. If you apply more than one discount to your subscription, the discount with the highest value will apply.

International

DS-01® Daily Synbiotic and PDS-08® Pediatric Daily Synbiotic ship internationally—you can learn about our international shipping options and where we ship here.

While VS-01™ doesn’t ship internationally yet, we're hoping to expand internationally in the future!

We offer a $10 USD flat rate shipping fee + any applicable local taxes/duties may apply.

Shipping is free for international members enrolled in our Sustainable Refill Program; you can enroll in your Account after your first order has processed.

Kindly note, any additional cost is solely taxes / duties imposed by your local government. We ship DDP, meaning duties and taxes are paid up front at checkout. We will recalculate duties and taxes for each shipment, but the price from order to order will typically remain the same unless there has been a change in your local jurisdiction’s policy.

International orders generally arrive 7–14 business days after they’ve shipped.