Microbiome 101

The 50% of you, you never met before.
04.06.18
Seed
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There’s a community of 38,000,000,000,000 (that’s 38 trillion) microorganisms, mostly bacteria, living in and on your body. The majority of them reside in your gastrointestinal tract, but many others live in diverse places like your mouth, your skin, and your armpits. They represent 50% of you by cell count. Collectively, the genes harbored in these trillions of microbial cells constitute your microbiome.

Wait. 38,000,000,000,000!?

Yep. Altogether, they weigh about 3-5 pounds (about the same as your brain).

But aren’t bacteria bad?

That’s the misconception of the century. Of the trillions of bacterial species that exist, we now know less than 100 pose a pathogenic threat to humans. Most are harmless (commensal). Many are beneficial (mutualistic). The ones that live in and on us are absolutely essential.

Where does my microbiome come from?

You probably remember from sixth grade biology that you inherit your genes from your parents. But did you know that your mother passes you your microbiome too? The process of receiving these foundational microbes is called seeding.

It’s generally regarded to start at birth (though new research is starting to propose that microbial transmission could occur in the womb via the placenta), through the vaginal canal, skin-to-skin contact, and breastfeeding. Eventually, the surrounding environment—other moms, dads, siblings, dogs, the ground, nature—continues to contribute to this microbial biodiversity.

These first microbes colonize your gastrointestinal system and form the foundation of your immune system, serving as the instructors of what’s dangerous and what’s not. By the first few years of life, they stabilize into what is called the steady-state microbiome, resembling more or less what you have today.

So what exactly do bacteria do in my body?

Well actually, what don’t they do? There’s almost no function in the human body that our bacterial symbionts and their metabolites aren’t connected to.

Let’s start with what you’ve probably already heard of—your gut. Trillions of beneficial bacteria reside along your epithelial wall and (partly by sheer strength in numbers) maintain your gut barrier integrity, making it difficult for inhospitable bacteria to penetrate. They help maintain an acidic environment to dissuade certain alkaline-loving pathogenic bacteria from taking root. They support the secretion of intestinal mucus and collaborate closely with your gut’s ‘gatekeepers’ (tight junctions) to modulate what should (ie. nutrients) or shouldn’t (ie. undigested food particles or pathogenic bacteria) pass through to the body. And certain bacteria even produce neurotransmitters that stimulate muscle contractions—yes, we’re talking about easier poops.

Gut epithelial cells

A close-up look at your gut lining.

When we eat, certain microbial genes code for enzymes that break down food we otherwise couldn’t—think complex carbohydrates, like fiber. Through this, bacteria also produce byproduct short-chain fatty acids, like butyrate, which fuel the cells lining your colon and strengthen your protective intestinal mucosa. Butyrate, specifically, has powerful anti-inflammatory effects beyond the gut, reducing oxidative stress (imbalance between free radicals and detoxifying antioxidants) and managing the production of regulatory T-cells (the ones that help your body distinguish between self and intruder).

Beyond this, bacteria also synthesize essential vitamins B and K, defend against E. coli and other intruders in the urogenital tract, and for women, balance pH and protect from unwanted yeast in the vaginal biome. Their health is critical to the health of our entire body—from heart to skin to metabolism to immune function.

All this to say that our bacteria play an incredibly complex and critical role in helping us thrive. Scientists are constantly discovering new associations between our microbiome and our health. New findings around the gut-brain axis are emerging which indicate that our gut flora may even impact our mood, appetite, behavior, and circadian rhythm—functions we thought were relegated just to the brain.


Seed101—What is the gut barrier, and how does it work?
The human intestinal lining is formed by a single layer of epithelial cells and a thick layer of mucus. This is what we call your gut barrier. It has two jobs: absorbing beneficial nutrients and providing protection against harmful substances. The space between each of your epithelial cells is sealed by tight junctions. Their job is to regulate the permeability of your gut barrier and act as the gatekeeper between the gut and the bloodstream.
With over 100 times the surface area of your skin (seriously, it’s the equivalent of two tennis courts and thickness of one cell wall, or half a human hair), the gut is the largest exposed external surface on your body. On a daily basis, it deals with the food you eat, the molecules you breathe, and at times, the potential toxins that look to get in. If your intestinal lining is damaged or compromised (you’ve probably heard of this being referred to as ‘leaky gut’), substances that don’t belong in your body can enter the bloodstream, triggering autoimmune responses in the body—think inflammation, allergies, irritable bowels, migraines, pain, fatigue, and more.

Are all our microbes the same?

Not at all! Like your genome, your microbiome is unique to you. And it’s changing, constantly. External factors like diet, exercise, medicine, and even sleep can all impact and alter the composition of your microbiome on a daily basis.

Imagine Earth’s ecosystems as an analogy of your own inner world. Over days and weeks and seasons and years, there may be different kinds of trees or plants or animals in different forests and deserts and oceans. But the ecological functions that make up that forest and keep each ecosystem thriving are continuous and conserved. In other words, our microbiomes are all vastly different from one another, but the functions they maintain for our health are relatively similar. Whatever microbes exist within us, they’ve evolved to be there.

Imagine Earth’s ecosystems as an analogy of your own inner world.

 

So how do I make sure my microbiome is healthy?

Well, here’s the thing. We don’t know what a healthy microbiome looks like. We may never. While it would be remarkable to say ‘you’re missing lactobacilli, here’s a supplement for it’, it’s simply not how science works. The ideal microbiome probably doesn’t exist. As diverse as we are, so are our microbiomes, and for good reason.

What you can ask is this—are my bacteria working optimally with my body to perform the functions critical to my health? How can I support my microbiome in the daily choices I make? Is the antibiotic my doctor just prescribed absolutely necessary? (link to first perturbations article on antibiotics) Am I eating for myself or also for my 38,000,000,000,000 within? (link to diet article) Should I be incorporating probiotics and prebiotics into my routine? (link to synbiotic article)

The study of the microbiome radically redefines our sense of self. Where we once thought ourselves fully human, we now know we are in fact, superorganisms, walking talking ecosystems—half human, half microbial.

This is the new biology. It demands a new approach to medicine, hygiene, diet, and health.


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